While over 150 thousand genomic sequences are currently available through dedicated repositories, ad hoc methods for the functional annotation of SARS-CoV-2 genomes do not harness all currently available resources for the annotation of functionally relevant genomic sites. Here we present CorGAT, a novel tool for the functional annotation of SARS-CoV-2 genomic variants. By comparisons with other state of the art methods we demonstrate that, by providing a more comprehensive and rich annotation, our method can facilitate the identification of evolutionary patterns in the genome of SARS-CoV-2.

CorGAT : a tool for the functional annotation of SARS-CoV-2 genomes / M. Chiara, F. Zambelli, M.A. Tangaro, P. Mandreoli, D.S. Horner, G. Pesole. - In: BIOINFORMATICS. - ISSN 1367-4803. - (2020 Dec 21). [Epub ahead of print]

CorGAT : a tool for the functional annotation of SARS-CoV-2 genomes

M. Chiara
;
F. Zambelli;P. Mandreoli;D.S. Horner;
2020

Abstract

While over 150 thousand genomic sequences are currently available through dedicated repositories, ad hoc methods for the functional annotation of SARS-CoV-2 genomes do not harness all currently available resources for the annotation of functionally relevant genomic sites. Here we present CorGAT, a novel tool for the functional annotation of SARS-CoV-2 genomic variants. By comparisons with other state of the art methods we demonstrate that, by providing a more comprehensive and rich annotation, our method can facilitate the identification of evolutionary patterns in the genome of SARS-CoV-2.
Settore BIO/11 - Biologia Molecolare
21-dic-2020
21-dic-2020
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/803170
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