We analyzed genetic data of 47,429 multiple sclerosis (MS) and 68,374 control subjects and established a reference map of the genetic architecture of MS that includes 200 autosomal susceptibility variants outside the major histocompatibility complex (MHC), one chromosome X variant, and 32 variants within the extended MHC. We used an ensemble of methods to prioritize 551 putative susceptibility genes that implicate multiple innate and adaptive pathways distributed across the cellular components of the immune system. Using expression profiles from purified human microglia, we observed enrichment for MS genes in these brain-resident immune cells, suggesting that these may have a role in targeting an autoimmune process to the central nervous system, although MS is most likely initially triggered by perturbation of peripheral immune responses.

Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility / M. Mitrovič, N. A Patsopoulos, A. H Beecham, T. Dankowski, A. Goris, B. Dubois, M. B D'hooghe, R. Lemmens, P. Van Damme, H. Bach Søndergaard, F. Sellebjerg, P. Soelberg Sorensen, H. Ullum, L. W Thørner, T. Werge, J. Saarela, I. Cournu-Rebeix, V. Damotte, B. Fontaine, L. Guillot-Noel, M. Lathrop, S. Vukusik, P. Gourraud, T.F. M Andlauer, V. Pongratz, D. Buck, C. Gasperi, A. Bayas, C. Heesen, T. Kümpfel, R. Linker, F. Paul, M. Stangel, B. Tackenberg, F. Then Bergh, C. Warnke, H. Wiendl, B. Wildemann, U. Zettl, U. Ziemann, H. Tumani, R. Gold, V. Grummel, B. Hemmer, B. Knier, C. M Lill, F. Luessi, E. Dardiotis, C. Agliardi, N. Barizzone, E. Mascia, L. Bernardinelli, G. Comi, D.M. Cusi, F. Esposito, L. Ferrè, C. Comi, D. Galimberti, M. A Leone, M. Sorosina, J. Mescheriakova, R. Hintzen, C. van Duijn, C. E Teunissen, S. D Bos, K. Myhr, E. G Celius, B. A Lie, A. Spurkland, M. Comabella, X. Montalban, L. Alfredsson, P. Stridh, J. Hillert, M. Jagodic, F. Piehl, I. Jelčić, R. Martin, M. Sospedra, B. Maria, C. Hawkins, P. Hysi, S. Kalra, F. Karpe, J. Khadake, G. Lachance, M. Neville, A. Santaniello, S. J Caillier, P. A Calabresi, B.A. C Cree, A. Cross, M. F Davis, J. L Haines, P.I. W de Bakker, S. Delgado, M. Dembele, K. Edwards, K. C Fitzgerald, H. Hakonarson, I. Konidari, E. Lathi, C. P Manrique, M. A Pericak-Vance, L.M. Piccio, C. Schaefer, C. McCabe, H. Weiner, J. Goldstein, T. Olsson, G. Hadjigeorgiou, B. Taylor, L. Tajouri, J. Charlesworth, D. R Booth, H. F Harbo, A. J Ivinson, S. L Hauser, A. Compston, G. Stewart, F. Zipp, L. F Barcellos, S. E Baranzini, F. Martinelli Boneschi, S. D'Alfonso, A. Ziegler, A. Oturai, J. L McCauley, S. J Sawcer, J. R Oksenberg, P. L De Jager, I. Kockum, D. A Hafler, C. Cotsapas. - In: SCIENCE. - ISSN 0036-8075. - 365:6460(2019 Sep 27), p. eaav7188.1417. [10.1126/science.aav7188]

Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

Cristina Agliardi;Giancarlo Comi;Daniele Cusi;Daniela Galimberti;Maria Ban;Laura Piccio;Filippo Martinelli-Boneschi;
2019-09-27

Abstract

We analyzed genetic data of 47,429 multiple sclerosis (MS) and 68,374 control subjects and established a reference map of the genetic architecture of MS that includes 200 autosomal susceptibility variants outside the major histocompatibility complex (MHC), one chromosome X variant, and 32 variants within the extended MHC. We used an ensemble of methods to prioritize 551 putative susceptibility genes that implicate multiple innate and adaptive pathways distributed across the cellular components of the immune system. Using expression profiles from purified human microglia, we observed enrichment for MS genes in these brain-resident immune cells, suggesting that these may have a role in targeting an autoimmune process to the central nervous system, although MS is most likely initially triggered by perturbation of peripheral immune responses.
Case-Control Studies; Cell Cycle Proteins; Chromosomes, Human, X; GTPase-Activating Proteins; Gene Frequency; Genetic Loci; Genomics; Humans; Inheritance Patterns; Major Histocompatibility Complex; Microglia; Multiple Sclerosis; Polymorphism, Single Nucleotide; Quantitative Trait Loci; RNA-Seq; Transcriptome; Chromosome Mapping; Genome-Wide Association Study
Settore MED/26 - Neurologia
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/744186
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