Muscular Dystrophies are severe genetic diseases due to mutations in structural genes, characterized by progressive muscle wasting that compromises patients' mobility and respiratory functions. Literature underlined oxidative stress and inflammation as key drivers of these pathologies. Interestingly among different myofiber classes, type I fibers display a milder dystrophic phenotype showing increased oxidative metabolism. This work shows the benefits of a cyanidin-enriched diet, that promotes muscle fiber-type switch and reduced inflammation in dystrophic alpha-sarcoglyan (Sgca) null mice having, as a net outcome, morphological and functional rescue. Notably, this benefit is achieved also when the diet is administered in dystrophic animals when the signs of the disease are seriously evident. Our work provides compelling evidence that a cyanidin-rich diet strongly delays the progression of muscular dystrophies, paving the way for a combinatorial approach where nutritional-based reduction of muscle inflammation and oxidative stress facilitate the successful perspectives of definitive treatments.
Nutritional intervention with cyanidin hinders the progression of muscular dystrophy / M. Saclier, C. Bonfanti, S. Antonini, G. Angelini, G. Mura, F. Zanaglio, V. Taglietti, V. Romanello, M. Sandri, C. Tonelli, K. Petroni, M. Cassano, G. Messina. - In: CELL DEATH & DISEASE. - ISSN 2041-4889. - 11:2(2020 Feb 18).
|Titolo:||Nutritional intervention with cyanidin hinders the progression of muscular dystrophy|
SACLIER, MARIELLE (Primo)
BONFANTI, CHIARA (Secondo)
CASSANO, MARCO (Penultimo)
MESSINA, GRAZIELLA (Ultimo) (Corresponding)
|Settore Scientifico Disciplinare:||Settore BIO/17 - Istologia|
Settore BIO/18 - Genetica
|Progetto:||Role of the transcription factor Nfix in muscle regeneration and muscular dystrophies (RegeneratioNfix)|
|Data di pubblicazione:||18-feb-2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1038/s41419-020-2332-4|
|Appare nelle tipologie:||01 - Articolo su periodico|