Age-related increases in circulating inflammatory markers in men are independent of BMI, blood pressure and blood lipid concentrations

Miles, E.A.; Rees, D.; Banerjee, T.; Cazzola, R.; Lewis, S.; Wood, R.; Oates, R.; Tallant, A.; Cestaro, B.; Yaqoob, P.; Wahle, K.W.J.; Calder, P.C.

doi:10.1016/j.atherosclerosis.2006.11.002

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Objective: To examine whether age-related increase in concentrations of circulating inflammatory mediators is due to concurrent increases in cardiovascular risk factors or is independent of these. Methods and results: Cytokines (IL-6, IL-18), chemokines (6Ckine, MCP-1, IP-10), soluble adhesion molecules (sICAM-1, sVCAM-1, sE-selectin) and adipokines (adiponectin) were measured in the plasma of healthy male subjects aged 18-84 years (n=162). These were related to known cardiovascular risk factors (age, BMI, systolic and diastolic blood pressure, plasma total cholesterol, LDL cholesterol, HDL cholesterol and triacylglycerol concentrations) in order to identify significant associations. Plasma concentrations of sVCAM-1, sE-selectin, IL-6, IL-18, MCP-1, 6Ckine, IP-10 and adiponectin, but not sICAM-1, were significantly positively correlated with age, as well as with several other cardiovascular risk factors. The correlations with other risk factors disappeared when age was controlled for. In contrast, the correlations with age remained significant for sVCAM-1, IL-6, MCP-1, 6Ckine and IP-10 when other cardiovascular risk factors were controlled for. Conclusions: Plasma concentrations of some inflammatory markers (sVCAM-1, IL-6, MCP-1, 6Ckine, IP-10) are positively correlated with age, independent of other cardiovascular risk factors. This suggests that age-related inflammation may not be driven by recognised risk factors.

Age-related increases in circulating inflammatory markers in men are independent of BMI, blood pressure and blood lipid concentrations / E.A. Miles, D. Rees, T. Banerjee, R. Cazzola, S. Lewis, R. Wood, R. Oates, A. Tallant, B. Cestaro, P. Yaqoob, K.W.J. Wahle, P.C. Calder. - In: ATHEROSCLEROSIS. - ISSN 0021-9150. - 196:1(2008), pp. 298-305.

Titolo:	Age-related increases in circulating inflammatory markers in men are independent of BMI, blood pressure and blood lipid concentrations
Autori:	E. A. Miles D. Rees T. Banerjee CAZZOLA, ROBERTA S. Lewis R. Wood R. Oates A. Tallant CESTARO, BENVENUTO ALESSANDRO P. Yaqoob K. W. J. Wahle P. C. Calder mostra contributor esterni nascondi contributor esterni
Parole Chiave:	aging; cardiovascular disease; chemokine; inflammation; soluble adhesion molecule
Settore Scientifico Disciplinare:	Settore BIO/10 - Biochimica
Data di pubblicazione:	2008
Rivista:	ATHEROSCLEROSIS
Tipologia:	Article (author)
Data ahead of print / Data di stampa:	21-nov-2006
Digital Object Identifier (DOI):	http://dx.doi.org/10.1016/j.atherosclerosis.2006.11.002
Appare nelle tipologie:	01 - Articolo su periodico

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