In this narrative review, we summarize recent pieces of evidence of the role of microbiota alterations in Rett syndrome (RTT). Neurological problems are prominent features of the syndrome, but the pathogenic mechanisms modulating its severity are still poorly understood. Gut microbiota was recently demonstrated to be altered both in animal models and humans with different neurodevelopmental disorders and/or epilepsy. By investigating gut microbiota in RTT cohorts, a less rich microbial community was identified which was associated with alterations of fecal microbial short-chain fatty acids. These changes were positively correlated with severe clinical outcomes. Indeed, microbial metabolites can play a crucial role both locally and systemically, having dynamic effects on host metabolism and gene expression in many organs. Similar alterations were found in patients with autism and down syndrome as well, suggesting a potential common pathway of gut microbiota involvement in neurodevelopmental disorders.
Rett Syndrome and Other Neurodevelopmental Disorders Share Common Changes in Gut Microbial Community : a Descriptive Review / E. Borghi, A. Vignoli. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1661-6596. - 20:17(2019 Aug 26), pp. 4160.1-4160.13.
|Titolo:||Rett Syndrome and Other Neurodevelopmental Disorders Share Common Changes in Gut Microbial Community : a Descriptive Review|
BORGHI, ELISA (Primo) [Conceptualization]
VIGNOLI, AGLAIA (Ultimo) [Conceptualization] (Corresponding)
|Parole Chiave:||autism spectrum disorder; Clostridium; gut microbiota; neurodevelopment; Rett syndrome; Sutterella|
|Settore Scientifico Disciplinare:||Settore MED/39 - Neuropsichiatria Infantile|
Settore MED/07 - Microbiologia e Microbiologia Clinica
|Data di pubblicazione:||26-ago-2019|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3390/ijms20174160|
|Appare nelle tipologie:||01 - Articolo su periodico|