The classical ketogenic diet (cKD) is an isocaloric, high fat, very low-carbohydrate diet that induces ketosis, strongly influencing leptin and ghrelin regulation. However, not enough is known about the impact of a long-term cKD. This study evaluated the effects of a 12-month cKD on ghrelin and leptin concentrations in children, adolescents and adults affected by the GLUT1-Deficiency Syndrome or drug resistant epilepsy (DRE). We also investigated the relationship between the nutritional status, body composition and ghrelin and leptin variations. We carried out a longitudinal study on 30 patients: Twenty-five children and adolescents (15 females, 8 ± 4 years), and five adults (two females, 34 ± 16 years). After 12-monoths cKD, there were no significant changes in ghrelin and leptin, or in the nutritional status, body fat, glucose and lipid profiles. However, a slight height z-score reduction (from -0.603 ± 1.178 to -0.953 ± 1.354, p ≤ 0.001) and a drop in fasting insulin occurred. We found no correlations between ghrelin changes and nutritional status and body composition, whereas leptin changes correlated positively with variations in the weight z-score and body fat (ρ = 0.4534, p = 0.0341; ρ = 0.5901, p = 0.0135; respectively). These results suggest that a long-term cKD does not change ghrelin and leptin concentrations independently of age and neurological condition.
Long-Term Effects of a Classic Ketogenic Diet on Ghrelin and Leptin Concentration : a 12-Month Prospective Study in a Cohort of Italian Children and Adults with GLUT1-Deficiency Syndrome and Drug Resistant Epilepsy / R. De Amicis, A. Leone, C. Lessa, A. Foppiani, S. Ravella, S. Ravasenghi, C. Trentani, C. Ferraris, P. Veggiotti, V. De Giorgis, A. Tagliabue, A. Battezzati, S. Bertoli. - In: NUTRIENTS. - ISSN 2072-6643. - 11:8(2019 Jul 25), pp. 1716.1-1716.15.
|Titolo:||Long-Term Effects of a Classic Ketogenic Diet on Ghrelin and Leptin Concentration : a 12-Month Prospective Study in a Cohort of Italian Children and Adults with GLUT1-Deficiency Syndrome and Drug Resistant Epilepsy|
DE AMICIS, RAMONA SILVANA (Primo) (Corresponding)
LEONE, ALESSANDRO (Secondo)
BERTOLI, SIMONA (Ultimo)
|Parole Chiave:||GLUT1-Deficiency Syndrome; drug-resistant epilepsy; ghrelin; ketogenic diet; leptin|
|Settore Scientifico Disciplinare:||Settore BIO/09 - Fisiologia|
Settore MED/49 - Scienze Tecniche Dietetiche Applicate
Settore MED/39 - Neuropsichiatria Infantile
|Data di pubblicazione:||25-lug-2019|
|Centro di ricerca:||Centro Internazionale per lo Studio della Composizione Corporea ICANS|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3390/nu11081716|
|Appare nelle tipologie:||01 - Articolo su periodico|