A sequence of seven reactions (stereocontrolled allylation, Mitsunobu reaction, ring closing metathesis, and amino/amido intramolecular nucleophilic addition) efficiently convert the inexpensive starting 2-piperidine ethanol into a small library of enatiomerically pure nitrogen containing compounds characterized by three new scaffolds that present a relevant diversity. This simple approach encroaches the further exploration of the chemical space.
Stereodivergent Diversity-Oriented Synthesis: Exploiting the Versatility of 2-Piperidine Ethanol / E. Bonandi, P. Marzullo, F. Foschi, D. Perdicchia, L.L. Presti, M. Sironi, S. Pieraccini, G. Gambacorta, J. Saupe, L. Dalla Via, D. Passarella. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1434-193X. - 2019:25(2019 Jul 07), pp. 4013-4019. [10.1002/ejoc.201900461]
Stereodivergent Diversity-Oriented Synthesis: Exploiting the Versatility of 2-Piperidine Ethanol
E. BonandiPrimo
;P. MarzulloSecondo
;D. Perdicchia;L.L. Presti;M. Sironi;S. Pieraccini;D. Passarella
Ultimo
2019
Abstract
A sequence of seven reactions (stereocontrolled allylation, Mitsunobu reaction, ring closing metathesis, and amino/amido intramolecular nucleophilic addition) efficiently convert the inexpensive starting 2-piperidine ethanol into a small library of enatiomerically pure nitrogen containing compounds characterized by three new scaffolds that present a relevant diversity. This simple approach encroaches the further exploration of the chemical space.
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Passarella manuscript Revised.pdf
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Bonandi_et_al-2019-European_Journal_of_Organic_Chemistry.pdf
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