LncRNA PCR arrays containing 90 common LncRNAs were used to screen lncRNA expression levels in PBMC from a discovery population of patients with MS. Data from discovery and replications cohorts showed a generalized dysregulation of lncRNA levels in MS patients compared with controls. MALAT1, MEG9, NRON, ANRIL, TUG1, XIST, SOX2OT, GOMAFU, HULC, BACE-1AS were significantly downregulated in MS patients in comparison with controls. Therefore, we performed a validation analysis in an independent cohort of Belgian origin. In this study, NRON and TUG1 downregulations in MS patients compared with controls were confirmed (p ≤.05 and p ≤.0001 respectively), whereas considering the other lncRNAs, the statistical threshold was not reached. LncRNAs profiling could thus represent a new challenge in the research of easy detectable biomarkers of disease susceptibility and progression.

LncRNAs expression profile in peripheral blood mononuclear cells from multiple sclerosis patients / C. Fenoglio, E. Oldoni, M. Serpente, M.A. De Riz, M. Arcaro, M. D'Anca, A.M. Pietroboni, A. Calvi, E. Lecchi, A. Goris, K. Mallants, B. Dubois, C. Comi, R. Cantello, E. Scarpini, D. Galimberti. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - 324(2018 Nov 15), pp. 129-135. [10.1016/j.jneuroim.2018.08.008]

LncRNAs expression profile in peripheral blood mononuclear cells from multiple sclerosis patients

C. Fenoglio
Primo
;
E. Oldoni
Secondo
;
M. Serpente;M. Arcaro;M. D'Anca;E.A. Scarpini
Penultimo
;
D. Galimberti
Ultimo
2018

Abstract

LncRNA PCR arrays containing 90 common LncRNAs were used to screen lncRNA expression levels in PBMC from a discovery population of patients with MS. Data from discovery and replications cohorts showed a generalized dysregulation of lncRNA levels in MS patients compared with controls. MALAT1, MEG9, NRON, ANRIL, TUG1, XIST, SOX2OT, GOMAFU, HULC, BACE-1AS were significantly downregulated in MS patients in comparison with controls. Therefore, we performed a validation analysis in an independent cohort of Belgian origin. In this study, NRON and TUG1 downregulations in MS patients compared with controls were confirmed (p ≤.05 and p ≤.0001 respectively), whereas considering the other lncRNAs, the statistical threshold was not reached. LncRNAs profiling could thus represent a new challenge in the research of easy detectable biomarkers of disease susceptibility and progression.
Biomarker; Gene expression; Multiple Sclerosis; Non coding RNA; Immunology and Allergy; Immunology; Neurology; Neurology (clinical)
Settore BIO/13 - Biologia Applicata
Settore MED/26 - Neurologia
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/621171
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