LncRNA PCR arrays containing 90 common LncRNAs were used to screen lncRNA expression levels in PBMC from a discovery population of patients with MS. Data from discovery and replications cohorts showed a generalized dysregulation of lncRNA levels in MS patients compared with controls. MALAT1, MEG9, NRON, ANRIL, TUG1, XIST, SOX2OT, GOMAFU, HULC, BACE-1AS were significantly downregulated in MS patients in comparison with controls. Therefore, we performed a validation analysis in an independent cohort of Belgian origin. In this study, NRON and TUG1 downregulations in MS patients compared with controls were confirmed (p ≤.05 and p ≤.0001 respectively), whereas considering the other lncRNAs, the statistical threshold was not reached. LncRNAs profiling could thus represent a new challenge in the research of easy detectable biomarkers of disease susceptibility and progression.
LncRNAs expression profile in peripheral blood mononuclear cells from multiple sclerosis patients / C. Fenoglio, E. Oldoni, M. Serpente, M.A. De Riz, M. Arcaro, M. D'Anca, A.M. Pietroboni, A. Calvi, E. Lecchi, A. Goris, K. Mallants, B. Dubois, C. Comi, R. Cantello, E. Scarpini, D. Galimberti. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - 324(2018 Nov 15), pp. 129-135.
|Titolo:||LncRNAs expression profile in peripheral blood mononuclear cells from multiple sclerosis patients|
FENOGLIO, CHIARA (Primo) (Corresponding)
OLDONI, EMANUELA (Secondo)
SCARPINI, ELIO ANGELO (Penultimo)
GALIMBERTI, DANIELA (Ultimo)
|Parole Chiave:||Biomarker; Gene expression; Multiple Sclerosis; Non coding RNA; Immunology and Allergy; Immunology; Neurology; Neurology (clinical)|
|Settore Scientifico Disciplinare:||Settore BIO/13 - Biologia Applicata|
Settore MED/26 - Neurologia
|Data di pubblicazione:||15-nov-2018|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.jneuroim.2018.08.008|
|Appare nelle tipologie:||01 - Articolo su periodico|