Introduction: Epigenetic modifications have recently been linked to neurodegenerative diseases, such as frontotemporal dementia (FTD), which represents the second most common form of dementia in adulthood after Alzheimer’s disease (AD). Epigenetic regulation occurs at different cellular levels and serve as a way to alter genetic information not only in aging but also following environmental signals. Thus, epigenetics mechanisms could exert their function at early stage of the disease, especially in sporadic cases. Areas covered: Herein, the available evidence supporting the concept that epigenetic-driven changes might shed the light into the pathogenic mechanisms of FTD will be summarized, with particular regard to their influence in underlying sporadic/familiar FTD onset and/or severity, and to the possibility to open a new scenario to facilitate early diagnosis and the identification of novel therapeutic targets. Bibliographic search through PubMed was used to find the studies included in this review. Expert commentary: Although epigenetic investigation in neurodegenerative disorders is in its infancy, recent advances in the technology of epigenetic change determination has led to novel, challenging findings. In particular, the knowledge and the characterization of epigenetic events could result in novel therapeutic strategies.
Epigenetic regulatory modifications in genetic and sporadic frontotemporal dementia / C. Fenoglio, E. Scarpini, D. Galimberti. - In: EXPERT REVIEW OF NEUROTHERAPEUTICS. - ISSN 1473-7175. - 18:6(2018 Jun 03), pp. 469-475.
|Titolo:||Epigenetic regulatory modifications in genetic and sporadic frontotemporal dementia|
FENOGLIO, CHIARA (Primo)
SCARPINI, ELIO ANGELO (Secondo)
GALIMBERTI, DANIELA (Ultimo) (Corresponding)
|Parole Chiave:||dementia; epigenetics; Microrna; non-coding RNA; risk factor; Neuroscience (all); Neurology (clinical); Pharmacology (medical)|
|Settore Scientifico Disciplinare:||Settore BIO/13 - Biologia Applicata|
Settore MED/26 - Neurologia
|Data di pubblicazione:||3-giu-2018|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1080/14737175.2018.1481389|
|Appare nelle tipologie:||01 - Articolo su periodico|