Spirulina is considered by the World Health Organization “one of the greatest superfood on the globe”. While many functional aspects have been investigated, the knowledge on its encrypted bioactive peptides is still scares. A high-throughput peptidomic strategy was applied to get insight into peptide expression and to screen their DPP-IV inhibitory activity. Spirulina proteins reveal different susceptibility to hydrolysis by pepsin (SP) and trypsin (ST). In the SP group 53 peptides were identified by LC-MS/MS, while 74 were characterized in the ST group. The maximum peptide MW distribution ranged between 1 and 1.5 kDa, for both groups, representing the 38% (SP) and 37% (ST) of total identified peptides, respectively. The inhibitory activity of SP and ST (5 mg/mL) against recombinant DPP-IV, was 41.1% and 37.92%, respectively, vs control. This results underline the great potential of microalgae hydrolysates in diabetes prevention providing useful information for functional foods development from spirulina.

Microalgae as source of bioactive peptides / Y. Li, C. Lammi, A. Arnoldi, G. Aiello. ((Intervento presentato al convegno ISNFF tenutosi a Vancouver nel 2018.

Microalgae as source of bioactive peptides

Y. Li;C. Lammi;A. Arnoldi
;
G. Aiello
2018-10-14

Abstract

Spirulina is considered by the World Health Organization “one of the greatest superfood on the globe”. While many functional aspects have been investigated, the knowledge on its encrypted bioactive peptides is still scares. A high-throughput peptidomic strategy was applied to get insight into peptide expression and to screen their DPP-IV inhibitory activity. Spirulina proteins reveal different susceptibility to hydrolysis by pepsin (SP) and trypsin (ST). In the SP group 53 peptides were identified by LC-MS/MS, while 74 were characterized in the ST group. The maximum peptide MW distribution ranged between 1 and 1.5 kDa, for both groups, representing the 38% (SP) and 37% (ST) of total identified peptides, respectively. The inhibitory activity of SP and ST (5 mg/mL) against recombinant DPP-IV, was 41.1% and 37.92%, respectively, vs control. This results underline the great potential of microalgae hydrolysates in diabetes prevention providing useful information for functional foods development from spirulina.
Settore CHIM/10 - Chimica degli Alimenti
Microalgae as source of bioactive peptides / Y. Li, C. Lammi, A. Arnoldi, G. Aiello. ((Intervento presentato al convegno ISNFF tenutosi a Vancouver nel 2018.
Conference Object
File in questo prodotto:
File Dimensione Formato  
Poster Vancouver Arnoldi 2018_CORRECT DIMENSIONS.pdf

accesso aperto

Tipologia: Altro
Dimensione 3.51 MB
Formato Adobe PDF
3.51 MB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/608479
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact