As a consequence of population aging, we have witnessed in internal medicine hospital wards a progressive shift from a population of in-patients relatively young and mainly affected by a single ailment to one of ever older and more and more complex patients with multiple chronic diseases, followed as out-patients by many different specialists with poor integration and inevitably treated with multiple medications. Polypharmacy (defined as the chronic intake of five or more drugs) is associated with increased risks of drug–drug interactions and related adverse effects, prescription and intake errors, poor compliance, re-hospitalization and mortality. With this background, the Italian Society of Internal Medicine chose to start in 2008 a prospective register called REPOSI (REgistro POliterapie SIMI, Società Italiana di Medicina Interna) in internal medicine and geriatric hospital wards. The country wide register is an ongoing observatory on multimorbidity and polypharmacy in the oldest old, with the goal to improve prescription appropriateness and, thus to avoid potentially inappropriate medications. The main findings of the register, that has accrued so far, 7005 older patients throughout a 10 year period, are summarized herewith, with special emphasis on the main patterns of poor prescription appropriateness and related risks of adverse events.
Polypharmacy in older people: lessons from 10 years of experience with the REPOSI register / P.M. Mannucci, A. Nobili, L. Pasina, P.M. Mannucci, M. Tettamanti, C. Franchi, S. Corrao, A. Marengoni, F. Salerno, M. Cesari, F. Perticone, G. Licata, F. Violi, G.R. Corazza, C. Franchi, L. Cortesi, M. Tettamanti, L. Cortesi, I. Ardoino, D. Prisco, E. Silvestri, C. Cenci, G. Emmi, G. Biolo, M. Zanetti, M. Guadagni, M. Zaccari, M. Vanoli, G. Grignani, E.A. Pulixi, M. Bernardi, S.L. Bassi, L. Santi, G. Zaccherini, E. Mannarino, G. Lupattelli, V. Bianconi, F. Paciullo, R. Nuti, R. Valenti, M. Ruvio, S. Cappelli, A. Palazzuoli, O. Olivieri, D. Girelli, T. Matteazzi, M. Barbagallo, L. Dominguez, F. Cocita, V. Beneduce, L. Plances, M. Zoli, I. Lazzari, M. Brunori, F.L. Pasini, P.L. Capecchi, G. Palasciano, M.E. Modeo, C. Di Gennaro, M.D. Cappellini, D. Maira, V. Di Stefano, G. Fabio, S. Seghezzi, M. Mancarella, M. Cesari, P.D. Rossi, S. Damanti, M. Clerici, F. Conti, G.R. Corazza, E. Miceli, M.V. Lenti, M. Pisati, C.C. Dominioni, G. Murialdo, A. Marra, F. Cattaneo, M.B. Secchi, D. Ghelfi, L. Anastasio, L. Sofia, M. Carbone, F. Cipollone, M.T. Guagnano, E. Angelucci, E. Valeriani, G. Mancuso, D. Calipari, M. Bartone, G. Delitala, M. Berria, M. Muscaritoli, A. Molfino, E. Petrillo, G. Zuccalà, G. D’Aurizio, G. Romanelli, A. Marengoni, A. Zucchelli, A. Picardi, U.V. Gentilucci, P. Gallo, C. Dell’Unto, G. Annoni, M. Corsi, G. Bellelli, S. Zazzetta, P. Mazzola, H. Szabo, A. Bonfanti, F. Arturi, E. Succurro, M. Rubino, M.G. Serra, M.A. Bleve, L. Gasbarrone, M.R. Sajeva, A. Brucato, S. Ghidoni, F. Fabris, I. Bertozzi, G. Bogoni, M.V. Rabuini, E. Cosi, R. Manfredini, F. Fabbian, B. Boari, A. De Giorgi, R. Tiseo, G. Paolisso, M.R. Rizzo, C. Borghi, E. Strocchi, V. De Sando, I. Pareo, C. Sabbà, F.S. Vella, P. Suppressa, P. Agosti, A. Schilardi, F. Loparco, L. Fenoglio, C. Bracco, A.V. Giraudo, S. Fargion, G. Periti, M. Porzio, S. Tiraboschi, F. Peyvandi, R. Rossio, B. Ferrari, G. Colombo, V. Monzani, V. Savojardo, C. Folli, G. Ceriani, F. Salerno, G. Pallini, F. Dallegri, L. Ottonello, L. Liberale, L. Caserza, K. Salam, N.L. Liberato, T. Tognin, G.B. Bianchi, S. Giaquinto, F. Purrello, A. Di Pino, S. Piro, R. Rozzini, L. Falanga, E. Spazzini, C. Ferrandina, G. Montrucchio, P. Petitti, R. Salmi, P. Gaudenzi, F. Violi, L. Perri, R. Landolfi, M. Montalto, A. Mirijello, L. Guasti, L. Castiglioni, A. Maresca, A. Squizzato, M. Molaro, A. Grossi, M. Bertolotti, C. Mussi, M.V. Libbra, G. Dondi, E. Pellegrini, L. Carulli, F. Perticone, L. Colangelo, T. Falbo, V. Stanghellini, R. De Giorgio, E. Ruggeri, S. del Vecchio, A. Salvi, R. Leonardi, G. Damiani, A. Gabrielli, W. Capeci, M. Mattioli, G.P. Martino, L. Biondi, P. Pettinari, R. Ghio, A.D. Col, S. Minisola, L. Colangelo, A. Afeltra, B. Marigliano, M.E. Pipita, P. Castellino, J. Blanco, L. Zanoli, S. Pignataro, V. Saracco, M. Fogliati, C. Bussolino, F. Mete, M. Gino, A. Cittadini, C. Vigorito, M. Arcopinto, A. Salzano, E. Bobbio, A.M. Marra, D. Sirico, G. Moreo, F. Gasparini, S. Prolo, G. Pina, A. Ballestrero, F. Ferrando, S. Berra, S. Dassi, M.C. Nava, B. Graziella, S. Baldassarre, S. Fragapani, G. Gruden, G. Galanti, G. Mascherini, C. Petri, L. Stefani, M. Girino, V. Piccinelli, F. Nasso, V. Gioffrè, M. Pasquale, G. Scattolin, S. Martinelli, M. Turrin, L. Sechi, C. Catena, G. Colussi, N. Passariello, L. Rinaldi, F. Berti, G. Famularo, T. Patrizia, R. Castello, M. Pasino, G.P. Ceda, M.G. Maggio, S. Morganti, A. Artoni, S. Del Giacco, D. Firinu, F. Losa, G. Paoletti, G. Montalto, A. Licata, V. Malerba, L. Antonino, G. Basile, C. Antonino, L. Malatino, B. Stancanelli, V. Terranova, S. Di Marca, P. Mecocci, C. Ruggiero, V. Boccardi, T. Meschi, F. Lauretani, A. Ticinesi, P. Minuz, L. Fondrieschi, M. Pirisi, G.P. Fra, D. Sola, M. Porta, P. Riva, R. Quadri, G. Scanzi, C. Mengoli, S. Provini, L. Ricevuti, E. Simeone, R. Scurti, F. Tolloso, R. Tarquini, A. Valoriani, S. Dolenti, G. Vannini, A. Tedeschi, L. Trotta, R. Volpi, P. Bocchi, A. Vignali, S. Harari, C. Lonati, M. Cattaneo, R.D. Nieves, M.M. Alberto, A.R. Pedro, L.P. Vanessa, T. Lara, C.V. Xavier, F. Francesc, D.M. Jesus, B.T. Esperanza, D.C.B. Esther, S.P. Maria, M. Romero, P.L. Blanca, L.G. Cristina, V.G.M. Victoria, L. Saez, J. Bosco, S.B. Susana, A.G. Marta, G.B. Concepcion, F.M. Antonio, M.G. Hernandez, M.P. Borrego, P.C. Raquel, P.R. Florencia, G.O. Beatriz, C.G. Sara, G.C. Alfonso, P.M. Marta, S.C. Garcia, R.C. Alberto, A.A. Antonio, G.G. Montserrat, B.R.M. Ángel, M.J. Manuel, N.V. Ignacio, A.S. Lucía, L. Alfonso, R.B. David, I.V. Iria, R.P. Monica, M.N. Cattaneo. - In: INTERNAL AND EMERGENCY MEDICINE. - ISSN 1828-0447. - 13:8(2018 Dec), pp. 1191-1200. [10.1007/s11739-018-1941-8]
Polypharmacy in older people: lessons from 10 years of experience with the REPOSI register
P.M. Mannucci
Primo
;C. FranchiMembro del Collaboration Group
;F. SalernoMembro del Collaboration Group
;M. CesariMembro del Collaboration Group
;C. FranchiMembro del Collaboration Group
;I. ArdoinoMembro del Collaboration Group
;E.A. PulixiMembro del Collaboration Group
;M.D. CappelliniMembro del Collaboration Group
;D. MairaMembro del Collaboration Group
;V. Di StefanoMembro del Collaboration Group
;G. Fabio;S. Seghezzi;M. Mancarella;M. Cesari;S. Damanti;M. Clerici;F. Conti;M.V. Lenti;M. Pisati;A. Brucato;P. Agosti;S. Fargion;G. Periti;M. Porzio;F. PeyvandiMembro del Collaboration Group
;R. RossioMembro del Collaboration Group
;B. FerrariMembro del Collaboration Group
;V. SavojardoMembro del Collaboration Group
;G. CerianiMembro del Collaboration Group
;F. SalernoMembro del Collaboration Group
;G. PalliniMembro del Collaboration Group
;A. Grossi;E. PellegriniMembro del Collaboration Group
;S. del VecchioMembro del Collaboration Group
;R. LeonardiMembro del Collaboration Group
;F. GaspariniMembro del Collaboration Group
;S. ProloMembro del Collaboration Group
;G. PinaMembro del Collaboration Group
;M. PasqualeMembro del Collaboration Group
;A. ArtoniMembro del Collaboration Group
;G. MontaltoMembro del Collaboration Group
;R. QuadriMembro del Collaboration Group
;S. Harari;C. LonatiMembro del Collaboration Group
;M.N. Cattaneo
2018
Abstract
As a consequence of population aging, we have witnessed in internal medicine hospital wards a progressive shift from a population of in-patients relatively young and mainly affected by a single ailment to one of ever older and more and more complex patients with multiple chronic diseases, followed as out-patients by many different specialists with poor integration and inevitably treated with multiple medications. Polypharmacy (defined as the chronic intake of five or more drugs) is associated with increased risks of drug–drug interactions and related adverse effects, prescription and intake errors, poor compliance, re-hospitalization and mortality. With this background, the Italian Society of Internal Medicine chose to start in 2008 a prospective register called REPOSI (REgistro POliterapie SIMI, Società Italiana di Medicina Interna) in internal medicine and geriatric hospital wards. The country wide register is an ongoing observatory on multimorbidity and polypharmacy in the oldest old, with the goal to improve prescription appropriateness and, thus to avoid potentially inappropriate medications. The main findings of the register, that has accrued so far, 7005 older patients throughout a 10 year period, are summarized herewith, with special emphasis on the main patterns of poor prescription appropriateness and related risks of adverse events.File | Dimensione | Formato | |
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