Herein, we performed a gene expression profiling in a cohort of 10 mild cognitive impairment (MCI), subdivided, according to the analysis of cerebrospinal fluid biomarkers, in prodromal Alzheimer's disease (AD) and non-AD MCI, as compared with 27 AD patients and 24 controls, in order to detect early gene expression alterations. We observed a significant upregulation of insulin (INS) and INS Receptor (INSR) expression levels in AD both prodromal and fully symptomatic, as compared with controls, but not in MCI subjects. Our results suggest an early dysregulation of INS and INSR in AD pathogenesis and pave the way to a possible utility of these transcripts as peripheral biomarkers.

Profiling of specific gene expression pathways in peripheral cells from prodromal Alzheimer's disease patients / M. Serpente, C. Fenoglio, S.M.G. Cioffi, E. Oldoni, M. Arcaro, A. Arighi, G.G. Fumagalli, L. Ghezzi, E. Scarpini, D. Galimberti. - In: JOURNAL OF ALZHEIMER'S DISEASE. - ISSN 1387-2877. - 61:4(2018), pp. 1289-1294. [10.3233/JAD-170861]

Profiling of specific gene expression pathways in peripheral cells from prodromal Alzheimer's disease patients

M. Serpente
Primo
;
C. Fenoglio
Secondo
;
S.M.G. Cioffi;E. Oldoni;M. Arcaro;A. Arighi;G.G. Fumagalli;L. Ghezzi;E. Scarpini
Penultimo
;
D. Galimberti
Ultimo
2018

Abstract

Herein, we performed a gene expression profiling in a cohort of 10 mild cognitive impairment (MCI), subdivided, according to the analysis of cerebrospinal fluid biomarkers, in prodromal Alzheimer's disease (AD) and non-AD MCI, as compared with 27 AD patients and 24 controls, in order to detect early gene expression alterations. We observed a significant upregulation of insulin (INS) and INS Receptor (INSR) expression levels in AD both prodromal and fully symptomatic, as compared with controls, but not in MCI subjects. Our results suggest an early dysregulation of INS and INSR in AD pathogenesis and pave the way to a possible utility of these transcripts as peripheral biomarkers.
Gene expression; insulin; insulin receptor; peripheral biomarkers; prodromal Alzheimer's disease; Neuroscience (all); Clinical Psychology; Geriatrics and Gerontology; Psychiatry and Mental Health
Settore MED/26 - Neurologia
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/598216
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