Increased levels ofMonocyteChemoattractant Protein (MCP)-1 have been found in cerebrospinal fluid from patients with frontotemporal lobar degeneration (FTLD), suggesting a role in neurodegeneration. 209 patients with sporadic FTLD were genotyped for the A-2518G single nucleotide polymorphism (SNP) in MCP-1 and compared with 203 age-matched controls. Asignificantly decreased allelic frequency of theGallele in patients as compared with controls was observed (21.1 vs. 29.3%, p = 0.010, OR: 0.59, CI: 0.40 – 0.87). Stratifying for gender, the significance was reached in males only, whereas no differences were observed stratifying for ApoE status. None of patients was a carrier of mutations in progranulin gene. Therefore, the A-2518G SNP likely represent a protective factor for the development of sporadic FTLD
The MCP-1 A-2518G polymorphism acts as proctective factor for frontotemporal lobar degeneration / C. Villa, E. Venturelli, C. Fenoglio, F. Clerici, A. Marcone, L. Benussi, F. Cortina, D. Scalabrini, L. Perini, G. Binetti, S. Cappa, C. Mariani, N. Bresolin, E. Scarpini, D. Galimberti. - In: CLINICAL NEUROPATHOLOGY. - ISSN 0722-5091. - 27:4(2008), pp. 285-285. (Intervento presentato al 44. convegno Congresso dell’Associazione Italiana di Neuropatologia (AINP) & Congresso dell’Associazione Italiana per la Ricerca sull’Invecchiamento Cerebrale (AIRIC) tenutosi a Milano nel 2008).
The MCP-1 A-2518G polymorphism acts as proctective factor for frontotemporal lobar degeneration
C. Villa;E. Venturelli;C. Fenoglio;D. Scalabrini;C. Mariani;N. Bresolin;E. Scarpini;D. Galimberti
2008
Abstract
Increased levels ofMonocyteChemoattractant Protein (MCP)-1 have been found in cerebrospinal fluid from patients with frontotemporal lobar degeneration (FTLD), suggesting a role in neurodegeneration. 209 patients with sporadic FTLD were genotyped for the A-2518G single nucleotide polymorphism (SNP) in MCP-1 and compared with 203 age-matched controls. Asignificantly decreased allelic frequency of theGallele in patients as compared with controls was observed (21.1 vs. 29.3%, p = 0.010, OR: 0.59, CI: 0.40 – 0.87). Stratifying for gender, the significance was reached in males only, whereas no differences were observed stratifying for ApoE status. None of patients was a carrier of mutations in progranulin gene. Therefore, the A-2518G SNP likely represent a protective factor for the development of sporadic FTLD
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