Heteronanoparticles (H-NPs) consisting of conjugates characterized by a squalene tail linked to doxorubicin and ecdysteroid derivatives are presented. Biological evaluation on A2780ADR cell line confirms not only the maintenance of the activity of the parental drug but also the ability to overcome cancer resistance. The in vitro cell uptake was demonstrated, and the involvement of an endosomal-mediated pathway was suggested.

Heteronanoparticles by Self-Assembly of Ecdysteroid and Doxorubicin Conjugates to Overcome Cancer Resistance / G. Fumagalli, G. Giorgi, M. Vágvölgyi, E. Colombo, M. Christodoulou, V. Collico, D. Prosperi, F. Dosio, A. Hunyadi, M. Montopoli, M. Hyeraci, A. Silvani, G. Lesma, L.D. Via, D. Passarella. - In: ACS MEDICINAL CHEMISTRY LETTERS. - ISSN 1948-5875. - 9:5(2018 Apr 17), pp. 468-471. [10.1021/acsmedchemlett.8b00078]

Heteronanoparticles by Self-Assembly of Ecdysteroid and Doxorubicin Conjugates to Overcome Cancer Resistance

G. Fumagalli;E. Colombo;M. Christodoulou;A. Silvani;G. Lesma;D. Passarella
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2018-04-17

Abstract

Heteronanoparticles (H-NPs) consisting of conjugates characterized by a squalene tail linked to doxorubicin and ecdysteroid derivatives are presented. Biological evaluation on A2780ADR cell line confirms not only the maintenance of the activity of the parental drug but also the ability to overcome cancer resistance. The in vitro cell uptake was demonstrated, and the involvement of an endosomal-mediated pathway was suggested.
cancer; doxorubicin; drug toxicity; ecdysteroids; self-assembled-nanoparticles; biochemistry; drug discovery3003 pharmaceutical science; organic chemistry
Settore CHIM/06 - Chimica Organica
Settore CHIM/08 - Chimica Farmaceutica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/576467
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