The “endocytic matrix reloaded” and its impact on the plasticity of migratory strategies

Background and aims: Phenylalanine (Phe) restricted diet, combined with Phe-free L-amino acid supplementation, is the mainstay of treatment for phenylketonuria (PKU). Being the diet a key factor modulating gut microbiota composition, the aim of the present paper was to compare dietary intakes, gut An explosive growth in knowledge, in the last two decades, has conferred a new dimension to the process of endocytosis. Endocytic circuitries have come into focus as a pervasive system that controls virtual all aspects of cell biology. A few years ago, we proposed the term “endocytic matrix” to define a cellular network of signalling wiring that is at the core of the cellular blueprint. A primary role of the endocytic matrix is the delivery of space- and time-resolved signals to the cell in an interpretable format, and, as such, it has profound consequences on polarized cellular and supra-cellular functions, first and foremost, cell motility. Here, we describe a set of recent results that expand this notion and illuminate how endocytic matrix dynamically controls the plasticity of migratory strategies. We further highlight the impact of inter-organelle contact sites on motility and the role of organelle positioning in this process. Finally, we illustrate how global perturbation of the endocytic circuitry influences cellular and supra-cellular mechanics, ultimately controlling a solid-to-liquid-like transition in the mode of motility with potential consequences on cancer dissemination.