High platelet to lymphocyte ratio (PLR) and neutrophil to lymphocyte ratio (NLR) are associated with an increased risk of arterial thrombosis, but their role in venous thromboembolism (VTE) has not been fully investigated. A caseâcontrol study, of 486 patients with VTE, 100 with cerebral vein thrombosis (CVT), and 299 healthy individuals, was carried out to investigate whether high PLR or NLR values are associated with an increased risk of VTE. Patients with high PLR or NLR did not have an increased risk of VTE (odds ratio [OR] 0.89, 95% confidence interval [CI]: 0.46-1.76; OR: 0.69, 95% CI: 0.34-1.39, respectively) or CVT (OR: 1.65, 95% CI: 0.68-4.00; OR: 0.39, 95% CI: 0.09-1.72, respectively). Subgroups analysis showed that high PLR values were associated with the risk of provoked CVT (OR: 2.65, 95% CI: 1.02-6.92), and there was an interaction with thrombophilia abnormalities (OR: 7.67, 95% CI: 1.67-35.27) in patients with CVT. In conclusion, high PLR and NLR values are not associated with an overall increased risk of VTE or CVT. High PLR values increase the risk of provoked CVT and interact with thrombophilia abnormalities in patients with CVT.
Platelet to Lymphocyte Ratio and Neutrophil to Lymphocyte Ratio as Risk Factors for Venous Thrombosis / A. Artoni, M. Abbattista, P. Bucciarelli, F. Gianniello, E. Scalambrino, E. Pappalardo, F. Peyvandi, I. Martinelli. - In: CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS. - ISSN 1076-0296. - 24:5(2018 Jul), pp. 808-814.
|Titolo:||Platelet to Lymphocyte Ratio and Neutrophil to Lymphocyte Ratio as Risk Factors for Venous Thrombosis|
ARTONI, ANDREA (Primo) (Corresponding)
PAYVANDI, FLORA (Penultimo)
|Parole Chiave:||deep venous thrombosis; inflammation; inflammation mediators; intracranial thrombosis; platelets; thrombophilia; hematology|
|Settore Scientifico Disciplinare:||Settore MED/09 - Medicina Interna|
|Data di pubblicazione:||lug-2018|
|Data ahead of print / Data di stampa:||2017|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1177/1076029617733039|
|Appare nelle tipologie:||01 - Articolo su periodico|