The preparation of hetero-nanoparticles (NPs) with doxorubicin (DOXO) and cyclopamine (CYP) conjugates is presented. Biological evaluation on A431 cell lines confirms the maintenance of the activity of the parental drugs. The in vivo study shows that self-assembled NPs reduce tumour growth and toxicity of chemotherapy.

Heteronanoparticles by self-Assembly of Doxorubicin and Cyclopamine Conjugates / G. Fumagalli, B. Stella, I. Pastushenko, F. Ricci, M.S. Christodoulou, G. Damia, D. Mazza, S. Arpicco, C. Giannini, L. Morosi, F. Dosio, P.A. Sotiropoulou, D. Passarella. - In: ACS MEDICINAL CHEMISTRY LETTERS. - ISSN 1948-5875. - 8:9(2017 Aug 01), pp. 953-957. [10.1021/acsmedchemlett.7b00262]

Heteronanoparticles by self-Assembly of Doxorubicin and Cyclopamine Conjugates

G. Fumagalli;M.S. Christodoulou;C. Giannini;D. Passarella
2017-08-01

Abstract

The preparation of hetero-nanoparticles (NPs) with doxorubicin (DOXO) and cyclopamine (CYP) conjugates is presented. Biological evaluation on A431 cell lines confirms the maintenance of the activity of the parental drugs. The in vivo study shows that self-assembled NPs reduce tumour growth and toxicity of chemotherapy.
cancer; cyclopamine; doxorubicin; drug toxicity; self-assembled-nanoparticles
Settore CHIM/06 - Chimica Organica
Settore CHIM/08 - Chimica Farmaceutica
ACS MEDICINAL CHEMISTRY LETTERS
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/521268
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