The study had the objective of evaluating the effects of a lupin protein concentrate on plasma lipids and other cardiovascular risk factors, e.g. blood pressure and insulin resistance, compared to a skimmed milk powder. Fifty subjects followed a randomised, parallel, double-blind, single-centre study, consisting in a 12-week intervention: half of the participants consumed a lupin protein concentrate (30 g/day of protein), the other half a lactose-free skimmed milk powder (30 g/day of protein), both integrated into a mixed low-lipid diet. At the end of intervention, both groups showed similar reductions of total cholesterol concentrations versus baseline (-6.7%, and -7.2%, respectively), but the reductions of LDL-cholesterol (-8.0%), non-HDL-cholesterol (-7.5%), and proprotein convertase subtilisin/kexin type 9 (PCSK9) (-12.7%) levels were statistically significant only after the lupin diet. A significant reduction of HDL-cholesterol concentration was observed only after the milk diet. The differences between the two groups, however, were not statistically significant.
Effects of a lupin protein concentrate on lipids, blood pressure and insulin resistance in moderately dyslipidaemic patients : a randomised controlled trial / C. Pavanello, C. Lammi, M. Ruscica, R. Bosisio, G. Mombelli, C. Zanoni, L. Calabresi, C.R. Sirtori, P. Magni, A. Arnoldi. - In: JOURNAL OF FUNCTIONAL FOODS. - ISSN 1756-4646. - 37(2017), pp. 8-15.
|Titolo:||Effects of a lupin protein concentrate on lipids, blood pressure and insulin resistance in moderately dyslipidaemic patients : a randomised controlled trial|
PAVANELLO, CHIARA (Primo)
LAMMI, CARMEN (Secondo)
MAGNI, PAOLO (Penultimo)
ARNOLDI, ANNA (Ultimo)
|Parole Chiave:||Blood pressure; Glycaemic control; Lipids; Lupin protein; PCSK9|
|Settore Scientifico Disciplinare:||Settore CHIM/10 - Chimica degli Alimenti|
Settore BIO/14 - Farmacologia
Settore MED/04 - Patologia Generale
Settore MED/05 - Patologia Clinica
|Data di pubblicazione:||2017|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.jff.2017.07.039|
|Appare nelle tipologie:||01 - Articolo su periodico|