IRIS Institutional Research Information System - AIR Archivio Istituzionale della Ricerca
IRIS è il sistema di gestione integrata dei dati della ricerca (persone, progetti, pubblicazioni, attività) adottato dall'Università degli Studi di Milano.
AIR nasce in UNIMI nel 2006 con lo scopo di raccogliere, documentare e conservare le informazioni sulla produzione scientifica dell'Università degli Studi di Milano e costituisce di fatto l'Anagrafe della ricerca dell'Ateneo.
EnglishBackground: Hepatitis C virus (HCV) chronically infects approximately 2% of the European population. Antiviral therapy with pegInterferon-α (PegIFN) and ribavirin (Rbv) is the standard of care, leading to HCV eradication in roughly 50% of patients. IFN-based therapy has been associated with high rates (20%) of central nervous system side effects, but only a few case reports exist on extrapyramidal side effects. Results: We report a 64-year-old man developing parkinsonism during PegIFN alfa-2a and ribavirin therapy for chronic hepatitis C. No improvement was observed after treatment discontinuation. Therefore, on the basis of previous clinical and experimental reports, levodopa-benserazide treatment was started. After substantial improvement, symptoms relapsed following drug tapering. Conclusions: This is the first case of parkinsonism in a Caucasian patient receiving PegIFN/Rbv therapy. The rapid and significant improvement of symptoms obtained in our patient with levodopa-benserazide, suggests that this therapy could be considered as first line symptomatic treatment.
| Titolo: | Recovery after L-DOPA treatment in peg-interferon and ribavirin induced parkinsonism |
| Autori: | BERSANO, ANNA (Primo) AGHEMO, ALESSIO MICHELE (Secondo) CANDELISE, LIVIA (Penultimo) COLOMBO, MASSIMO GIUSEPPE (Ultimo) |
| Parole Chiave: | HCV; Levodopa; Parkinsonism; PegInterferon; Side effects |
| Settore Scientifico Disciplinare: | Settore MED/12 - Gastroenterologia |
| Data di pubblicazione: | 2008 |
| Rivista: | |
| Tipologia: | Article (author) |
| Digital Object Identifier (DOI): | 10.1016/j.ejim.2007.10.003 |
| Appare nelle tipologie: | 01 - Articolo su periodico |
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