Background: A subset of celiac patients shows a high risk for small bowel malignancies. Aims: To select celiac patients considered at risk and evaluate the diagnostic yield of enteroscopy in this context. Methods: Celiac patients were enrolled from a tertiary referral centre during the period June 2011-June 2013, based on the following criteria: (i) patients diagnosed when aged 50+ and with poor response to gluten-free dieting; (ii) low dietary compliance; (iii) alarm symptoms. The patients underwent small bowel capsule endoscopy and/or double-balloon enteroscopy. Control populations were represented by the 165 non-celiac patients undergoing capsule endoscopy for obscure gastrointestinal bleeding, and the 815,362-strong population of the Italian province of Varese as a registered cohort. Results: Fifty-three patients (19% males, mean age 43.6. ±. 17.4 years) were evaluated. Two jejunal adenocarcinomas and one ileal neuro-endocrine tumour were diagnosed by enteroscopy (the diagnostic yield for malignancies in the selected population being 5.7%). In the non-celiac controls the detection rate of small bowel tumours by capsule endoscopy was 0.6% (P= 0.04). When compared to the registered population, the relative risk for intestinal malignancy was 1282 (95% CI, 407-4033; P< 0.0001). Conclusions: Capsule endoscopy and double-balloon enteroscopy can be considered for early disease management of a subset of celiac patients.
Enteroscopy for the early detection of small bowel tumours in at-risk celiac patients / C. Tomba, L. Elli, M.T. Bardella, M. Soncini, P. Contiero, L. Roncoroni, M. Locatelli, D. Conte. - In: DIGESTIVE AND LIVER DISEASE. - ISSN 1590-8658. - 46:5(2014), pp. 400-404.
|Titolo:||Enteroscopy for the early detection of small bowel tumours in at-risk celiac patients|
TOMBA, CAROLINA (Corresponding)
ELLI, LUCA (Secondo)
CONTE, DARIO (Ultimo)
|Parole Chiave:||celiac disease; enteroscopy; malignancies; small bowel; adenocarcinoma; adult; anemia; celiac disease; early detection of cancer; female; humans; ileal neoplasms; jejunal neoplasms; male; middle aged; neuroendocrine tumors; patient selection; prospective studies; risk factors; capsule endoscopy; double-balloon enteroscopy; gastroenterology; hepatology; medicine (all)|
|Settore Scientifico Disciplinare:||Settore MED/12 - Gastroenterologia|
|Data di pubblicazione:||2014|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.dld.2013.12.009|
|Appare nelle tipologie:||01 - Articolo su periodico|