In the present study we chemically profiled tannin-enriched extracts from strawberries and tested their biological properties in a cell model of gastric inflammation. The chemical and biological features of strawberry tannins after in vitro simulated gastric digestion were investigated as well. The anti-inflammatory activities of pure strawberry tannins were assayed to get mechanistic insights. Tannin-enriched extracts from strawberries inhibit IL-8 secretion in TNFα-treated human gastric epithelial cells by dampening the NF-κB signaling. In vitro simulated gastric digestion slightly affected the chemical composition and the biological properties of strawberry tannins. By using pure compounds, we found that casuarictin may act as a pure NF-κB inhibitor while agrimoniin inhibits IL-8 secretion also acting on other biological targets; in our system procyanidin B1 prevents the TNFα-induced effects without interfering with the NF-κB pathway. We conclude that strawberry tannins, even after in vitro simulated gastric digestion, exert anti-inflammatory activities at nutritionally relevant concentrations.
Strawberry tannins inhibit IL-8 secretion in a cell model of gastric inflammation / M. Fumagalli, E. Sangiovanni, U. Vrhovsek, S. Piazza, E. Colombo, M. Gasperotti, F. Mattivi, E. De Fabiani, M. Dell'Agli. - In: PHARMACOLOGICAL RESEARCH. - ISSN 1043-6618. - 111(2016 Sep 01), pp. 703-712.
|Titolo:||Strawberry tannins inhibit IL-8 secretion in a cell model of gastric inflammation|
FUMAGALLI, MARCO (Primo)
SANGIOVANNI, ENRICO (Secondo)
DE FABIANI, EMMA SELINA ROSA (Penultimo)
DELL'AGLI, MARIO (Corresponding)
|Parole Chiave:||Ellagitannins; Fragaria spp; Gastric inflammation; IL-8; Procyanidins; Strawberry; Pharmacology|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
Settore BIO/10 - Biochimica
|Data di pubblicazione:||1-set-2016|
|Data ahead of print / Data di stampa:||27-lug-2016|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.phrs.2016.07.028|
|Appare nelle tipologie:||01 - Articolo su periodico|