Background: To describe the clinical features of patients with seizure onset within the first three years of life, and to evaluate risk factors for long-term prognosis. Methods: We selected 266 patients among 3096 individuals consecutively observed at a single Epilepsy Center between 1992 and 2012, and retrospectively analyzed their clinical, EEG, neuro-radiological and genetic characteristics. Results: Mean ages at epilepsy onset and at follow-up were 14.9 months and 29.3 years, respectively. Mean follow-up period 8.2 years. We identified a recognizable etiology in 147 individuals (55.2%), while 76 (28.6%) were Thirty-four patients (27.9%) had a confirmed genetic diagnosis and 12 (9.8%) had a meta-bolic diagnosis. Febrile seizures (p = 0.008), positive family history (p = 0.049), drug resistance (p = 0.048), moderate (p = 0.04) and severe intellectual disability (p = 0.005) were significantly more frequent in patients with seizure onset 0-12 months than in those with onset 13-36 months. Multiple regression analysis demonstrated a link between early age of epilepsy onset and intellectual disability (p = 0.008). No further variables were significantly associated with age at epilepsy onset (for etiology p = 0.095, for drug resistance p = 0.646, and for neuro-radiological findings p = 0.087). Conclusion: Our study demonstrated worse outcome in symptomatic epilepsies in a large and representative sample. We also confirmed that the earlier age at seizure onset, the poorest the epilepsy outcome.
Long-term outcome of epilepsy with onset in the first three years of life: findings from a large cohort of patients / A. Vignoli, A. Peron, K. Turner, G.F. Scornavacca, F. La Briola, V. Chiesa, E. Zambrelli, M.P. Canevini. - In: EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY. - ISSN 1090-3798. - 20:4(2016 Jul), pp. 566-572.
|Titolo:||Long-term outcome of epilepsy with onset in the first three years of life: findings from a large cohort of patients|
VIGNOLI, AGLAIA (Corresponding)
PERON, ANGELA (Secondo)
CANEVINI, MARIA PAOLA (Ultimo)
|Parole Chiave:||Early onset epilepsy; Intellectual disability; Seizures; Long-term outcome; Etiology|
|Settore Scientifico Disciplinare:||Settore MED/39 - Neuropsichiatria Infantile|
|Data di pubblicazione:||lug-2016|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.ejpn.2016.03.008|
|Appare nelle tipologie:||01 - Articolo su periodico|