Background: This study was designed to evaluate Streptococcus pneumoniae (S. pneumoniae) carriage rates in patients with cystic fibrosis (CF). Methods: An oropharyngeal swab was obtained from 212 CF children and adolescents enrolled during routine clinical visits. DNA from swabs was analyzed by real-time polymerase chain reaction. Results: A total of 42 (19.8%) CF patients (mean age ± standard deviation [SD], 12.0 ± 3.3 years) were colonized by S. pneumoniae. Carriage was more common in younger patients and tended to decline with age. Administration of systemic and/or inhaled antibiotics in the last 3 months significantly correlated with a reduced carrier state [odds ratio (OR) 0.23, 95% confidence interval (CI) 0.07-0.69, and OR 0.26, 95% CI 0.08-0.77, respectively]. Vitamin D serum levels ≥. 30 ng/mL were less common in carriers than that in non-carriers (OR 0.35; 95% CI 0.08-1.49). In both the vaccinated and unvaccinated subjects, serotypes 19F, 5, 4, and 9V were the most commonly carried serotypes. Conclusions: S. pneumoniae carrier state of school-age children and adolescents with CF is more prevalent than previously thought, and pneumococcal conjugate vaccination administered in the first year of life does not reduce the risk of re-colonization in later childhood and adolescence.
Streptococcus pneumoniae oropharyngeal colonization in children and adolescents with cystic fibrosis / S. Esposito, C. Colombo, A. Tosco, E. Montemitro, S. Volpi, L. Ruggiero, M. Lelii, A. Bisogno, C. Pelucchi, N. Principi, L. Terranova, A. Zampiero, V. Montinaro, V. Ierardi, M. Gambino, F. Corti, R. Moresco, V. Raia, F. Impronta, V. Lucidi, M. Passiu, I. Meneghelli. - In: JOURNAL OF CYSTIC FIBROSIS. - ISSN 1569-1993. - 15:3(2016 May), pp. 366-371.
|Titolo:||Streptococcus pneumoniae oropharyngeal colonization in children and adolescents with cystic fibrosis|
|Parole Chiave:||cystic fibrosis; pneumococcal carrier; pneumococcal colonization; pneumococcal conjugate vaccine; pneumococcal vaccination; streptococcus pneumoniae; pulmonary and respiratory medicine; pediatrics, perinatology and child health|
|Settore Scientifico Disciplinare:||Settore MED/38 - Pediatria Generale e Specialistica|
|Data di pubblicazione:||mag-2016|
|Data ahead of print / Data di stampa:||3-giu-2015|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.jcf.2015.05.008|
|Appare nelle tipologie:||01 - Articolo su periodico|