Maytenus senegalensis (Lam.) Excell (Celastraceae) root extracts were investigated for their topical antiinflammatory properties by measuring the inhibition of the Croton oil-induced ear oedema in mice. The highest anti-inflammatory activity was detected in the chloroform extract, which reduced the oedematous response with a 2 potency similar to that of the NSAID reference drug indomethacin (ID50 = 84 and 93 mu g/cm(2), respectively). Fractionation of the chloroform and of the hexane extracts led to the isolation of maytenoic acid (1), which exhibited a dose-dependent antiphlogistic effect (ID50 = 0.11 mu mol/cm(2)) twice that of indomethacin (ID50 = 0.26 mu mol/cm(2)) and only three times lower than that of hydrocortisone (ID50 = 0.04 mu mol/Crn).
Anti-inflammatory activity of Maytenus senegalensis root extracts and of maytenoic acid / S. Sosa, C. Morelli, A. Tubaro, P. Cairoli, G. Speranza, P. Manitto. - In: PHYTOMEDICINE. - ISSN 0944-7113. - 14:2-3(2007), pp. 109-114.
Anti-inflammatory activity of Maytenus senegalensis root extracts and of maytenoic acid
C. MorelliSecondo
;P. Cairoli;G. SperanzaPenultimo
;P. ManittoUltimo
2007
Abstract
Maytenus senegalensis (Lam.) Excell (Celastraceae) root extracts were investigated for their topical antiinflammatory properties by measuring the inhibition of the Croton oil-induced ear oedema in mice. The highest anti-inflammatory activity was detected in the chloroform extract, which reduced the oedematous response with a 2 potency similar to that of the NSAID reference drug indomethacin (ID50 = 84 and 93 mu g/cm(2), respectively). Fractionation of the chloroform and of the hexane extracts led to the isolation of maytenoic acid (1), which exhibited a dose-dependent antiphlogistic effect (ID50 = 0.11 mu mol/cm(2)) twice that of indomethacin (ID50 = 0.26 mu mol/cm(2)) and only three times lower than that of hydrocortisone (ID50 = 0.04 mu mol/Crn).File | Dimensione | Formato | |
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