Duchenne muscular dystrophy (DMD) is a lethal disease. The outcome measures used in numerous therapeutic trials include skeletal muscle biopsy. We studied the natural history of DMD from the standpoint of muscle histology with the aim of providing a reproducible tool for use in evaluating and comparing any histologic changes occurring in patients with DMD undergoing treatment and hence be able to determine how therapy modulates the histologic evolution of the disease.

Histologic muscular history in steroid-treated and untreated patients with Duchenne dystrophy / L. Peverelli, S. Testolin, L. Villa, A. D'Amico, S. Petrini, C. Favero, F. Magri, L. Morandi, M. Mora, T. Mongini, E. Bertini, M. Sciacco, G.P. Comi, M. Moggio. - In: NEUROLOGY. - ISSN 0028-3878. - 85:21(2015 Nov 24), pp. 1886-1893.

Histologic muscular history in steroid-treated and untreated patients with Duchenne dystrophy

L. Peverelli;S. Testolin;L. Villa;C. Favero;F. Magri;G.P. Comi;
2015-11-24

Abstract

Duchenne muscular dystrophy (DMD) is a lethal disease. The outcome measures used in numerous therapeutic trials include skeletal muscle biopsy. We studied the natural history of DMD from the standpoint of muscle histology with the aim of providing a reproducible tool for use in evaluating and comparing any histologic changes occurring in patients with DMD undergoing treatment and hence be able to determine how therapy modulates the histologic evolution of the disease.
Settore MED/26 - Neurologia
NEUROLOGY
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/342589
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