Can biliary endoscopy play a role in liver disease associated to cystic fibrosis?

Biliopathy associated to cystic fibrosis (CF) is a relatively rare condition in adult patients. Recently, an increase in life expectancy for patients with cystic fibrosis (CF) has been reported. Therefore, a new clinical picture related to CF- associated liver involvement is quite often observed [1]. The involvement of the biliary tree has been hypothesized as having a pivotal role in the pathogenesis and evolution of liver cirrhosis, but there is a lack of systematic data about it [1,2]. The impact of endotherapy on the biliopathy and liver disease in adult cystic fibrosis patients needs sistematic evaluation with a long-term follow-up.