Cysteinyl-leukotrienes (cysteinyl-LTs), i.e. LTC4, LTD4, and LTE4, trigger contractile and inflammatory responses through the specific interaction with G protein-coupled receptors (GPCRs) belonging to the purine receptor cluster of the rhodopsin family, and identified as CysLT receptors (CysLTRs). Cysteinyl-LTs have a clear role in pathophysiological conditions such as asthma and allergic rhinitis, and have been implicated in other inflammatory conditions including cardiovascular diseases, cancer, atopic dermatitis and urticaria. Molecular cloning of human CysLT1R and CysLT2R subtypes has confirmed most of the previous pharmacological characterization and identified distinct expression patterns only partially overlapping. Interestingly, recent data provide evidence for the immunomodulation of CysLTR expression, the existence of additional receptor subtypes, and of an intracellular pool of CysLTRs that may have roles different from those of plasma membrane receptors. Furthermore, genetic variants have been identified for the CysLTRs that may interact to confer risk for atopy. Finally, a crosstalk between the cysteinyl-LT and the purine systems is being delineated. This review will summarize and attempt to integrate recent data derived from studies on the molecular pharmacology and pharmacogenetics of CysLTRs, and will consider the therapeutic opportunities arising from the new roles suggested for cysteinyl-LTs and their receptors

Cysteinyl-leukotrienes and their receptors in asthma and other inflammatory diseases: Critical update and emerging trends / V. Capra, M.D. Thompson, A. Sala, D.E. Cole, G. Folco, G. Rovati. - In: MEDICINAL RESEARCH REVIEWS. - ISSN 0198-6325. - 27:4(2007), pp. 469-527.

Cysteinyl-leukotrienes and their receptors in asthma and other inflammatory diseases: Critical update and emerging trends

V. Capra;A. Sala;G. Folco;G. Rovati
2007

Abstract

Cysteinyl-leukotrienes (cysteinyl-LTs), i.e. LTC4, LTD4, and LTE4, trigger contractile and inflammatory responses through the specific interaction with G protein-coupled receptors (GPCRs) belonging to the purine receptor cluster of the rhodopsin family, and identified as CysLT receptors (CysLTRs). Cysteinyl-LTs have a clear role in pathophysiological conditions such as asthma and allergic rhinitis, and have been implicated in other inflammatory conditions including cardiovascular diseases, cancer, atopic dermatitis and urticaria. Molecular cloning of human CysLT1R and CysLT2R subtypes has confirmed most of the previous pharmacological characterization and identified distinct expression patterns only partially overlapping. Interestingly, recent data provide evidence for the immunomodulation of CysLTR expression, the existence of additional receptor subtypes, and of an intracellular pool of CysLTRs that may have roles different from those of plasma membrane receptors. Furthermore, genetic variants have been identified for the CysLTRs that may interact to confer risk for atopy. Finally, a crosstalk between the cysteinyl-LT and the purine systems is being delineated. This review will summarize and attempt to integrate recent data derived from studies on the molecular pharmacology and pharmacogenetics of CysLTRs, and will consider the therapeutic opportunities arising from the new roles suggested for cysteinyl-LTs and their receptors
Cysteinyl-leukotriene receptors; asthma; allergic rhinitis; cardiovascular diseases; cancer.
Settore BIO/14 - Farmacologia
MEDICINAL RESEARCH REVIEWS
http://www3.interscience.wiley.com/cgi-bin/abstract/112747874/ABSTRACT?CRETRY=1&SRETRY=0
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/29796
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