The ability of a quadrivalent human papilloma virus (HPV)-16/18/6/11 virus-like particles vaccine (Gardasil) to elicit HPV-specific cell-mediated immune responses was evaluated in antiretroviral therapy (ART)-treated HIV-infected young adults. Results showed that, after three doses of vaccine, central memory and effector memory CD4(+) and CD8(+) T lymphocytes, as well as HPV-specific interleukin (IL)2(+)/CD4(+), interferon-gamma (IFN-γ(+))/CD4(+), IFN-γ(+)/CD8(+) and tumour necrosis factor-alpha (TNF-α)(+)/CD8(+) T lymphocytes and Perforin and Granzyme B secreting CD8(+) T lymphocytes were significantly increased. Notably, results obtained in HIV-infected patients were comparable to those seen in HIV-uninfected age-matched healthy controls.
Human papilloma virus vaccination induces strong human papilloma virus specific cell-mediated immune responses in HIV-infected adolescents and young adults / V. Rainone, V. Giacomet, F. Penagini, V. Fabiano, F. Calascibetta, C. Mameli, S. Pisanelli, G.V. Zuccotti, M. Clerici, D. Trabattoni. - In: AIDS. - ISSN 0269-9370. - 29:6(2015 Mar 27), pp. 739-743.
Titolo: | Human papilloma virus vaccination induces strong human papilloma virus specific cell-mediated immune responses in HIV-infected adolescents and young adults |
Autori: | |
Parole Chiave: | human-immunodeficiency-virus; active antiretroviral therapy; disease progression; immunogenicity; safety; impact |
Settore Scientifico Disciplinare: | Settore MED/38 - Pediatria Generale e Specialistica |
Data di pubblicazione: | 27-mar-2015 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1097/QAD.0000000000000597 |
Appare nelle tipologie: | 01 - Articolo su periodico |
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