A sustainable and scalable process for the production of a new mixture of fructooligosaccharides (FOS) was developed using a continuous-flow approach based on an immobilized whole cells-packed bed reactor. The technological transfer from a classical batch system to an innovative flow environment allowed a significant improvement of the productivity. Moreover, the stability of this production system was ascertained by up to 7 days of continuous working. These results suggest the suitability of the proposed method for a large-scale production of the desired FOS mixture, in view of a foreseeable use as a novel prebiotic preparation.

An efficient continuous flow process for the synthesis of a non-conventional mixture of fructooligosaccharides / P. Zambelli, L. Tamborini, S. Cazzamalli, A. Pinto, S. Arioli, S. Balzaretti, F.J. Plou, L. Fernandez Arrojo, F. Molinari, P. Conti, D. Romano. - In: FOOD CHEMISTRY. - ISSN 0308-8146. - 190(2016 Jan 01), pp. 607-613.

An efficient continuous flow process for the synthesis of a non-conventional mixture of fructooligosaccharides

P. Zambelli
Primo
;
L. Tamborini
Secondo
;
A. Pinto;S. Arioli;S. Balzaretti;F. Molinari;P. Conti
Penultimo
;
D. Romano
Ultimo
2016

Abstract

A sustainable and scalable process for the production of a new mixture of fructooligosaccharides (FOS) was developed using a continuous-flow approach based on an immobilized whole cells-packed bed reactor. The technological transfer from a classical batch system to an innovative flow environment allowed a significant improvement of the productivity. Moreover, the stability of this production system was ascertained by up to 7 days of continuous working. These results suggest the suitability of the proposed method for a large-scale production of the desired FOS mixture, in view of a foreseeable use as a novel prebiotic preparation.
fructooligosaccharides; flow chemistry; cladosporium cladosporioides; Dried alginate entrapped enzymes (DALGEE); prebiotics
Settore CHIM/11 - Chimica e Biotecnologia delle Fermentazioni
Settore CHIM/08 - Chimica Farmaceutica
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/281950
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