Reactive carbonyl species generated by lipid peroxidation are involved in several human diseases and may represent a novel drug target. RCS therefore represent a new biological target for drug discovery. The reaction mechanisms and structural features characterising effective aldehyde-sequestering agents are highlighted, as are the fundamental biochemical and pharmacological screening tools to be applied in the development of RCS scavengers.
Lipoxidation-derived reactive carbonyl species as potential drug targets in preventing protein carbonylation and related cellular dysfunction / G. Aldini, I. Dalle-Donne, R. Colombo, R. Maffei Facino, A. Milzani, M. Carini. - In: CHEMMEDCHEM. - ISSN 1860-7179. - 1:10(2006), pp. 1045-1058.
Lipoxidation-derived reactive carbonyl species as potential drug targets in preventing protein carbonylation and related cellular dysfunction
G. AldiniPrimo
;I. Dalle-DonneSecondo
;R. Colombo;R. Maffei Facino;A. MilzaniPenultimo
;M. CariniUltimo
2006
Abstract
Reactive carbonyl species generated by lipid peroxidation are involved in several human diseases and may represent a novel drug target. RCS therefore represent a new biological target for drug discovery. The reaction mechanisms and structural features characterising effective aldehyde-sequestering agents are highlighted, as are the fundamental biochemical and pharmacological screening tools to be applied in the development of RCS scavengers.
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