BACKGROUNDClinical evidence supports the relationship between carbonyl stress and type II diabetes and its related pathologies. Methylglyoxal (MGO) is the major dicarbonyl compound involved in carbonyl stress. Efforts are therefore being made to find dietary compounds from natural sources that could exert an MGO trapping response. RESULTSThe in vitroMGO trapping capacity of six red and seven white grape skin extracts (GSE) obtained from winemaking by-products was investigated. Methanolic GSE exhibited a promising MGO trapping capacity that was higher in red GSE (IC50 2.8mg mL(-1)) when compared with white GSE (IC50 3.2mg mL(-1)). The trapping ability for red GSE correlated significantly with total phenolic content and antioxidant capacity. However, no correlations were observed for white GSE, which suggests that other compounds were involved in the trapping activity. CONCLUSIONGSE may be considered a natural source of carbonyl stress inhibitors, thus opening up its possible utilization as a nutraceutical ingredient. Further investigations are required to understand the mechanism involved in the carbonyl trapping ability of red and white grape skin samples and their relationship with glycation.
Grape skin extracts from winemaking by-products as a source of trapping agents for reactive carbonyl species / P.S.C. Sri Harsha, M. Mesias, V. Lavelli, F.J. Morales. - In: JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE. - ISSN 0022-5142. - 96:2(2016 Jan 30), pp. 656-663.
|Titolo:||Grape skin extracts from winemaking by-products as a source of trapping agents for reactive carbonyl species|
PEDAPATI, SIVA CHARAN SRI HARSHA (Primo)
LAVELLI, VERA AGNESE (Penultimo)
|Parole Chiave:||trapping; methylglyoxal; dicarbonyl compounds; antiglycation; grape skin|
|Settore Scientifico Disciplinare:||Settore AGR/15 - Scienze e Tecnologie Alimentari|
|Data di pubblicazione:||30-gen-2016|
|Data ahead of print / Data di stampa:||23-mar-2015|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1002/jsfa.7137|
|Appare nelle tipologie:||01 - Articolo su periodico|