Emerging evidence underlines the importance of micro(mi)RNAs in the pathogenesis of multiple sclerosis (MS). Free-circulating miRNAs were investigated in serum from MS patients compared to controls. Statistically significant decreased levels of miR-15b, miR-23a and miR-223 were observed in MS patients (p < 0.05). Results were validated and replicated in two further independent MS populations. A direct correlation between miRNA levels and the EDSS score was determined in PPMS (p < 0.007). The generalized trend toward miRNA down-regulation could result in over-expression of target genes involved in disease pathogenesis. Circulating miRNA profiling could thus represent a new avenue to identify easily detectable disease biomarkers. © The Author(s) 2013.
Decreased circulating miRNA levels in patients with primary progressive multiple sclerosis / C. Fenoglio, E. Ridolfi, C. Cantoni, M. De Riz, R. Bonsi, M. Serpente, C. Villa, A.M. Pietroboni, R.T. Naismith, E. Alvarez, B.J. Parks, N. Bresolin, A.H. Cross, L.M. Piccio, D. Galimberti, E. Scarpini. - In: MULTIPLE SCLEROSIS. - ISSN 1352-4585. - 19:14(2013), pp. 1938-1942. [10.1177/1352458513485654]
Decreased circulating miRNA levels in patients with primary progressive multiple sclerosis
C. Fenoglio
;E. RidolfiSecondo
;C. Cantoni;M. De Riz;R. Bonsi;M. Serpente;C. Villa;N. Bresolin;D. GalimbertiPenultimo
;E. ScarpiniUltimo
2013
Abstract
Emerging evidence underlines the importance of micro(mi)RNAs in the pathogenesis of multiple sclerosis (MS). Free-circulating miRNAs were investigated in serum from MS patients compared to controls. Statistically significant decreased levels of miR-15b, miR-23a and miR-223 were observed in MS patients (p < 0.05). Results were validated and replicated in two further independent MS populations. A direct correlation between miRNA levels and the EDSS score was determined in PPMS (p < 0.007). The generalized trend toward miRNA down-regulation could result in over-expression of target genes involved in disease pathogenesis. Circulating miRNA profiling could thus represent a new avenue to identify easily detectable disease biomarkers. © The Author(s) 2013.
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