A novel class of transcripts, long non coding RNAs (lncRNAs), has recently emerged as key players in several biological processes, including dosage compensation, genomic imprinting, chromatin regulation, embryonic development and segmentation, stem cell pluripotency, cell fate determination and potentially many other biological processes, which still are to be elucidated. LncRNAs are pervasively transcribed in the genome and several lines of evidence correlate dysregulation of different lncRNAs to human diseases including neurological disorders. Although their mechanisms of action are yet to be fully elucidated, evidence suggests lncRNA contributions to the pathogenesis of a number of diseases. In this review, the current state of knowledge linking lncRNAs to different neurological disorders is discussed and potential future directions are considered. © 2013 by the authors; licensee MDPI, Basel, Switzerland.

An emerging role for long non-coding RNA dysregulation in neurological disorders [Recensione] / C. Fenoglio, E. Ridolfi, D. Galimberti, E. Scarpini. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1661-6596. - 14:10(2013 Oct), pp. 20427-20442.

An emerging role for long non-coding RNA dysregulation in neurological disorders

C. Fenoglio;E. Ridolfi;D. Galimberti;E. Scarpini
2013

Abstract

A novel class of transcripts, long non coding RNAs (lncRNAs), has recently emerged as key players in several biological processes, including dosage compensation, genomic imprinting, chromatin regulation, embryonic development and segmentation, stem cell pluripotency, cell fate determination and potentially many other biological processes, which still are to be elucidated. LncRNAs are pervasively transcribed in the genome and several lines of evidence correlate dysregulation of different lncRNAs to human diseases including neurological disorders. Although their mechanisms of action are yet to be fully elucidated, evidence suggests lncRNA contributions to the pathogenesis of a number of diseases. In this review, the current state of knowledge linking lncRNAs to different neurological disorders is discussed and potential future directions are considered. © 2013 by the authors; licensee MDPI, Basel, Switzerland.
Epigenetics; LncRNA; Neurodegenerative diseases; RNA; Animals; Humans; Nervous System Diseases; RNA, Long Noncoding; Computer Science Applications1707 Computer Vision and Pattern Recognition; Molecular Biology; Catalysis; Inorganic Chemistry; Spectroscopy; Organic Chemistry; Physical and Theoretical Chemistry
Settore MED/26 - Neurologia
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/251397
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