The Mediterranean diet reduces the risk of coronary artery disease as a consequence of its high content of antioxidants, namely, hydroxytyrosol (HT) and oleuropein aglycone (OleA), typical of virgin olive oil. Because intercellular and vascular cell adhesion molecules (ICAM-1 and VCAM-1) and E-selectin are crucial for endothelial activation, the role of the phenolic extract from extra virgin olive oil (OPE), OleA, HT, and homovanillyl alcohol (HVA) on cell surface and mRNA expression in human umbilical vascular endothelial cells (HUVEC) was evaluated. OPE strongly reduced cell surface expression of ICAM-1 and VCAM-1 at concentrations physiologically relevant (IC50 < 1 AM), linked to a reduction in mRNA levels. OleA and HT were the main components responsible for these effects. HVA inhibited cell surface expression of all the adhesion molecules, whereas the effect on mRNA expression was weaker. These results supply new insights on the protective role of olive oil against vascular risk through the down-regulation of adhesion molecules involved in early atherogenesis

Minor components of olive oil modulate proatherogenic adhesion molecules involved in endothelial activation / M. DELL'AGLI, R. FAGNANI, N. MITRO, S. SCURATI, M. MASCIADRI, L. MUSSONI, G.V. GALLI, E. BOSISIO, M. CRESTANI, E. DE FABIANI, E. TREMOLI, D. CARUSO. - In: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. - ISSN 0021-8561. - 54:9(2006), pp. 3259-3264.

Minor components of olive oil modulate proatherogenic adhesion molecules involved in endothelial activation

M. DELL'AGLI
Primo
;
R. FAGNANI
Secondo
;
N. MITRO;S. SCURATI;M. MASCIADRI;L. MUSSONI;G.V. GALLI;E. BOSISIO;M. CRESTANI;E. DE FABIANI;E. TREMOLI
Penultimo
;
D. CARUSO
Ultimo
2006

Abstract

The Mediterranean diet reduces the risk of coronary artery disease as a consequence of its high content of antioxidants, namely, hydroxytyrosol (HT) and oleuropein aglycone (OleA), typical of virgin olive oil. Because intercellular and vascular cell adhesion molecules (ICAM-1 and VCAM-1) and E-selectin are crucial for endothelial activation, the role of the phenolic extract from extra virgin olive oil (OPE), OleA, HT, and homovanillyl alcohol (HVA) on cell surface and mRNA expression in human umbilical vascular endothelial cells (HUVEC) was evaluated. OPE strongly reduced cell surface expression of ICAM-1 and VCAM-1 at concentrations physiologically relevant (IC50 < 1 AM), linked to a reduction in mRNA levels. OleA and HT were the main components responsible for these effects. HVA inhibited cell surface expression of all the adhesion molecules, whereas the effect on mRNA expression was weaker. These results supply new insights on the protective role of olive oil against vascular risk through the down-regulation of adhesion molecules involved in early atherogenesis
olive oil; proatherogenic adhesion molecules; endothelial activation; ICAM-1; VCAM-1; hydroxytyrosol; oleuropein aglycone; E-selectin
Settore BIO/10 - Biochimica
Settore BIO/15 - Biologia Farmaceutica
Settore BIO/14 - Farmacologia
http://pubs.acs.org/cgi-bin/article.cgi/jafcau/2006/54/i09/pdf/jf0529161.pdf
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/24208
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