Fennel allergy has been rarely reported, and the association with peach allergy has never been described. Our aim was to (i) study the correlation between symptom severity of peach and fennel and (ii) identify fennel allergens and the role of rPru p 3 antibodies in severe reactions to fennel. In 148 patients with peach allergy, we investigated 58 patients with symptoms and IgE antibodies positive to fennel. IgE to rPru p 1, 3, and 4 and rBet v 1, 2, and 4 were measured by immunoblotting, and the N-terminal amino acid sequences and relevant allergens were determined. We found significant association between severe reactions to fennel and peach (p = 0.0009). A major allergen was ~9 kDa lipid-transfer protein (LTP), cross-reactive with Pru p 3, a 15 kDa protein identified as a pathogenesis-related protein 1 of the Bet v 1 family. In conclusion, peach and fennel severe allergic symptoms are significantly related, and LTP is a major fennel allergen. Fennel should be included in the LTP syndrome.
Fennel allergy is a lipid-transfer protein (LTP)-related food hypersensitivity associated with peach allergy / E.A. Pastorello, L. Farioli, C. Stafylaraki, J. Scibilia, M.G. Giuffrida, A. Mascheri, M. Piantanida, C. Baro, L. Primavesi, M. Nichelatti, J.W. Schroeder, V. Pravettoni. - In: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. - ISSN 0021-8561. - 61:3(2013 Jan 23), pp. 740-746.
Fennel allergy is a lipid-transfer protein (LTP)-related food hypersensitivity associated with peach allergy
E.A. PastorelloPrimo
;C. Stafylaraki;A. Mascheri;M. Piantanida;L. Primavesi;
2013
Abstract
Fennel allergy has been rarely reported, and the association with peach allergy has never been described. Our aim was to (i) study the correlation between symptom severity of peach and fennel and (ii) identify fennel allergens and the role of rPru p 3 antibodies in severe reactions to fennel. In 148 patients with peach allergy, we investigated 58 patients with symptoms and IgE antibodies positive to fennel. IgE to rPru p 1, 3, and 4 and rBet v 1, 2, and 4 were measured by immunoblotting, and the N-terminal amino acid sequences and relevant allergens were determined. We found significant association between severe reactions to fennel and peach (p = 0.0009). A major allergen was ~9 kDa lipid-transfer protein (LTP), cross-reactive with Pru p 3, a 15 kDa protein identified as a pathogenesis-related protein 1 of the Bet v 1 family. In conclusion, peach and fennel severe allergic symptoms are significantly related, and LTP is a major fennel allergen. Fennel should be included in the LTP syndrome.File | Dimensione | Formato | |
---|---|---|---|
PAstorello FENNEL Journal of agricultural and food chemistry 2013-740.pdf
accesso riservato
Tipologia:
Publisher's version/PDF
Dimensione
2.91 MB
Formato
Adobe PDF
|
2.91 MB | Adobe PDF | Visualizza/Apri Richiedi una copia |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.