Design and Synthesis of a new class of GTPase protein Rac1 inhibitor are described. The entire class called AR were designed based on a crystal structure of the complex Rac1-NS23766. The main features of the synthetic strategy are discussed and permitted the obtainment in satisfactory yield of all the designed compound.
Design, synthesis and pharmacological evaluation of new Rac1 protein inhibitors / A. Ruffoni, F. Clerici, A. Contini, N. Ferri. ((Intervento presentato al convegno ArmChemFront, Frontiers in Chemistry tenutosi a Yerevan nel 2013.
Design, synthesis and pharmacological evaluation of new Rac1 protein inhibitors
A. RuffoniPrimo
;F. ClericiSecondo
;A. ContiniPenultimo
;N. FerriUltimo
2013
Abstract
Design and Synthesis of a new class of GTPase protein Rac1 inhibitor are described. The entire class called AR were designed based on a crystal structure of the complex Rac1-NS23766. The main features of the synthetic strategy are discussed and permitted the obtainment in satisfactory yield of all the designed compound.
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