Cell-bound lipases of dry mycelium of Aspergillus oryzae were used in organic solvent for the resolution of racemic flurbiprofen by direct esterification with ethanol in a flow-chemistry reactor. Under flow conditions a significant reduction of the reaction time and an increase of the enantioselectivity were achieved compared to the batch mode. Moreover, the process was implemented by adding an in-line purification step integrated with the racemization of the unreacted flurbiprofen directly into a polymer-supported resin.
Biotransformation with whole microbial systems in a continuous flow reactor : resolution of (RS)-flurbiprofen using Aspergillus oryzae by direct esterification with ethanol in organic solvent / L. Tamborini, D. Romano, A. Pinto, M. Contente, M.C. Iannuzzi, P. Conti, F. Molinari. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - 54:45(2013), pp. 6090-6093.
Titolo: | Biotransformation with whole microbial systems in a continuous flow reactor : resolution of (RS)-flurbiprofen using Aspergillus oryzae by direct esterification with ethanol in organic solvent |
Autori: | TAMBORINI, LUCIA (Primo) ROMANO, DIEGO (Secondo) CONTI, PAOLA (Penultimo) MOLINARI, FRANCESCO ENZO (Ultimo) |
Parole Chiave: | Enzymatic resolution; Dry mycelia; Flow reactor; Flurbiprofen; Aspergillus oryzae |
Settore Scientifico Disciplinare: | Settore CHIM/08 - Chimica Farmaceutica Settore CHIM/11 - Chimica e Biotecnologia delle Fermentazioni |
Data di pubblicazione: | 2013 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.tetlet.2013.08.119 |
Appare nelle tipologie: | 01 - Articolo su periodico |
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