Oxatomide at therapeutic doses generates occasionally drowsiness in children. When administered at toxic doses, however oxatomide may induce long lasting impaired consciousness. We now report a case of severe long lasting impaired consciousness induced by therapeutic doses of oxatomide occurring in a child affected by acute gastroenteritis. The clinical symptoms, the pharmacogenetic tests of polymorphisms in cytochrome P450 metabolizing enzymes (CYPs) and the clinical and laboratory analyses indicate that the enhanced drug sedative effect is likely due to an acute, yet mild, inflammatory state of the patient. These findings highlight the importance of assessing common, not serious inflammatory states when oxatomide is prescribed in paediatric patients.

Inflammation and neurological adverse drugs reactions : a case of long lasting impaired consciousness after oxatomide administration in a patient with gastroenteritis / S. Antoniazzi, D. Cattaneo, V. Perrone, C. Carnovale, S. Cherubini, M. Mugolino, F. Clementi, G. Zuccotti, E. Clementi, S. Radice. - In: THE ITALIAN JOURNAL OF PEDIATRICS. - ISSN 1720-8424. - 38:1(2012 Mar 30), pp. 11.1-11.3. [10.1186/1824-7288-38-11]

Inflammation and neurological adverse drugs reactions : a case of long lasting impaired consciousness after oxatomide administration in a patient with gastroenteritis

S. Antoniazzi;D. Cattaneo;V. Perrone;C. Carnovale;S. Cherubini;F. Clementi;G. Zuccotti;E. Clementi;S. Radice
2012

Abstract

Oxatomide at therapeutic doses generates occasionally drowsiness in children. When administered at toxic doses, however oxatomide may induce long lasting impaired consciousness. We now report a case of severe long lasting impaired consciousness induced by therapeutic doses of oxatomide occurring in a child affected by acute gastroenteritis. The clinical symptoms, the pharmacogenetic tests of polymorphisms in cytochrome P450 metabolizing enzymes (CYPs) and the clinical and laboratory analyses indicate that the enhanced drug sedative effect is likely due to an acute, yet mild, inflammatory state of the patient. These findings highlight the importance of assessing common, not serious inflammatory states when oxatomide is prescribed in paediatric patients.
Adverse drug reaction; CYPs; Inflammation; Long lasting impaired consciousness; Oxatomide
Settore MED/38 - Pediatria Generale e Specialistica
30-mar-2012
Article (author)
File in questo prodotto:
File Dimensione Formato  
antoniazzi1824-7288-38-11.pdf

accesso aperto

Tipologia: Publisher's version/PDF
Dimensione 179.08 kB
Formato Adobe PDF
179.08 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/224709
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 6
  • ???jsp.display-item.citation.isi??? 4
social impact