Members of the IL-1 family play a key role in innate and adaptive immunity and in the pathogenesis of diverse diseases. Members of IL-1R like receptor (ILR) family include signaling molecules and negative regulators. The latter include decoy receptors (IL-1RII; IL-18BP) and “receptors” with regulatory function (TIR8/SIGIRR; IL-1RAcPb; DIGIRR). Structural considerations suggest that also TIGIRR-1 and IL-1RAPL may have regulatory function. The presence of multiple pathways of negative regulation of members of the IL-1/IL-1R family emphasizes the need for a tight control of members of this fundamental system.

Decoys and Regulatory Receptors of the IL-1/Toll-Like Receptor Superfamily / C. Garlanda, F. Riva, E. Bonavita, S. Gentile, A. Mantovani. - In: FRONTIERS IN IMMUNOLOGY. - ISSN 1664-3224. - 4(2013 Jul 09), pp. 180.1-180.13.

Decoys and Regulatory Receptors of the IL-1/Toll-Like Receptor Superfamily

F. Riva
Secondo
;
S. Gentile
Penultimo
;
A. Mantovani
Ultimo
2013

Abstract

Members of the IL-1 family play a key role in innate and adaptive immunity and in the pathogenesis of diverse diseases. Members of IL-1R like receptor (ILR) family include signaling molecules and negative regulators. The latter include decoy receptors (IL-1RII; IL-18BP) and “receptors” with regulatory function (TIR8/SIGIRR; IL-1RAcPb; DIGIRR). Structural considerations suggest that also TIGIRR-1 and IL-1RAPL may have regulatory function. The presence of multiple pathways of negative regulation of members of the IL-1/IL-1R family emphasizes the need for a tight control of members of this fundamental system.
cytokine; interleukin-1; inflammation; decoy receptor
Settore VET/05 - Malattie Infettive degli Animali Domestici
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/223636
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