Cloning of the cDNA coding for the 270-residue turtle prion protein is reported. It represents the most remote example thus far described. The entire coding region is comprised in a single exon, while a large intron interrupts the 5' UTR. The common structural features of the known prion proteins are all conserved in turtle PrP, whose identity degree to mammalian and avian proteins is about 40 and 58%, respectively. The most intriguing feature, unique to the turtle prion, is the presence of an EF-hand Ca(2+) binding motif in the C-terminal half of the protein.

cDNA cloning of turtle prion protein / T. Simonic, S. Duga, B. Strumbo, R. Asselta, F. Ceciliani, S. Ronchi. - In: FEBS LETTERS. - ISSN 0014-5793. - 469:1(2000 Mar 03), pp. 33-38.

cDNA cloning of turtle prion protein

T. Simonic
Primo
;
S. Duga
Secondo
;
B. Strumbo;R. Asselta;F. Ceciliani
Penultimo
;
S. Ronchi
Ultimo
2000

Abstract

Cloning of the cDNA coding for the 270-residue turtle prion protein is reported. It represents the most remote example thus far described. The entire coding region is comprised in a single exon, while a large intron interrupts the 5' UTR. The common structural features of the known prion proteins are all conserved in turtle PrP, whose identity degree to mammalian and avian proteins is about 40 and 58%, respectively. The most intriguing feature, unique to the turtle prion, is the presence of an EF-hand Ca(2+) binding motif in the C-terminal half of the protein.
cDNA cloning; EF-hand Ca2+ binding motif; Gene organization; Reptile prion protein
Settore BIO/11 - Biologia Molecolare
3-mar-2000
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/208461
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