Recent evidence supports the existence of adult mammalian stem cell subpopulations, particularly within the bone marrow, that may be able to "transdifferentiate" across tissue lineage boundaries, thus offering an accessible source for therapeutic applications even for neural tissue repair. However, the difficulties in reproducing some experimental data, the rarity of the transdifferentiation events and observations that cell fusion may be an alternative explanation argue against the idea of stem cell plasticity. Investigations going beyond descriptive experiments and more mechanicistic approaches may provide a more solid foundation to adult stem cell therapeutic potential.

Somatic stem cell research for neural repair : current evidence and emerging perspectives / S.P. Corti, F. Locatelli, D. Papadimitriou, S. Strazzer, G.P. Comi. - In: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. - ISSN 1582-1838. - 8:3(2004), pp. 329-337.

Somatic stem cell research for neural repair : current evidence and emerging perspectives

S.P. Corti
Primo
;
G.P. Comi
Ultimo
2004

Abstract

Recent evidence supports the existence of adult mammalian stem cell subpopulations, particularly within the bone marrow, that may be able to "transdifferentiate" across tissue lineage boundaries, thus offering an accessible source for therapeutic applications even for neural tissue repair. However, the difficulties in reproducing some experimental data, the rarity of the transdifferentiation events and observations that cell fusion may be an alternative explanation argue against the idea of stem cell plasticity. Investigations going beyond descriptive experiments and more mechanicistic approaches may provide a more solid foundation to adult stem cell therapeutic potential.
Animals ; Multipotent Stem Cells ; Cell Lineage ; Cell Fusion ; Humans ; Mesenchymal Stem Cell Transplantation ; Cell Differentiation ; Stem Cells ; Neurodegenerative Diseases ; Stem Cell Transplantation ; Bone Marrow Transplantation
Settore MED/26 - Neurologia
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/205952
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