The present paper is a comprehensive review of available data concerning the role of radiotherapy as an intended curative treatment in patients with non-small cell lung cancer (NSCL). The following issues are reviewed (1) optimal dose, (2) optimal fractionation, (3) optimal treatment planning, (4) clinical results in terms of single treatment and combined treatment with either surgery or chemotherapy. In resectable NSCLC high dose ratiotherapy to small localized tumours gives a 5-year survival rate of 7-38%. It is concluded that this treatment modality is appropriate for certain selected patients who refuse to have surgery, who have medical contradictions for surgery, or who are of old age. It is discussed whether the treatment should be split course, continuous, hypo-og hyperfraction. A total dose of 55 Gy must be given. CT scanning should be mandatory for optimal planning and therapy. The literature does not give a conclusive answer to whether preoperative or postoperative radiotherapy is indicated. The data indicate that patients with Stage III NSCLC will benefit from a combined treatment modality in terms of chemotherapy based on high dose cisplatinum and radiotherapy. The main conclusion of the review is that many areas with randomized controlled trials are needed in order to answer the critical issue of the role of radiotherapy in the treatment of NSCLS.
Tracheal sleeve pneumonectomy for lung cancer / G.C. Roviaro, C. Rebuffat, F. Varoli, S. Scalambra, C. Vergani, M.L. Maciocco, E. Sibilla, A. Sonnino. - In: LUNG CANCER. - ISSN 0169-5002. - 11:Suppl.1(1994 Jun), pp. 153-153. ((Intervento presentato al 7. convegno World Conference on lung cancer tenutosi a Colorado Springs nel 1994.
|Titolo:||Tracheal sleeve pneumonectomy for lung cancer|
ROVIARO, GIAN CARLO (Primo)
REBUFFAT, CARLO (Secondo)
|Parole Chiave:||Combination modality; Post-operative radiotherapy; Pre-operative radiotherapy; Treatment of NSCLC; Treatment schedules; Unresectable NSCLC|
|Settore Scientifico Disciplinare:||Settore MED/18 - Chirurgia Generale|
Settore MED/21 - Chirurgia Toracica
|Data di pubblicazione:||giu-1994|
|Enti collegati al convegno:||The International Association for the Study of Lung Cancer (IASLC)|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/0169-5002(94)94364-8|
|Appare nelle tipologie:||01 - Articolo su periodico|