Olive oil phenolic constituents have been shown, in vitro, to be endowed with potent biological activities including, but not limited to, an antioxidant action. To date, there is no information on the absorption and disposition of such compounds in humans. We report that olive oil phenolics, namely tyrosol and hydroxytyrosol, are dose-dependently absorbed in humans after ingestion and that they are excreted in the urine as glucuronide conjugates. Furthermore, an increase in the dose of phenolics administered increased the proportion of conjugation with glucuronide.
|Titolo:||Olive oil phenolics are dose-dependently absorbed in humans|
|Parole Chiave:||Plant Oils; Dietary Fats, Unsaturated; Antioxidants; Phenylethyl Alcohol; Humans; Adult; Intestinal Absorption; Phenols; Male|
|Settore Scientifico Disciplinare:||Settore BIO/10 - Biochimica|
Settore BIO/14 - Farmacologia
|Data di pubblicazione:||25-feb-2000|
|Digital Object Identifier (DOI):||10.1016/S0014-5793(00)01216-3|
|Appare nelle tipologie:||01 - Articolo su periodico|