Synthesis of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes by cycloaddition and subsequent cross-coupling reaction is described. Binding affinity of these novel compounds towards the characteristic receptorial targets of ibogaine is illustrated. (C) 2002 Elsevier Science Lid. All rights reserved.
Ibogaine analogues. Synthesis and preliminary pharmacological evaluation of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes / D. Passarella, R. Favia, A. Giardini, G. Lesma, M. Martinelli, A. Silvani, B. Danieli, S. Efange, D. Mash. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 0968-0896. - 11:6(2003), pp. 1007-1014. [10.1016/S0968-0896(02)00524-2]
Ibogaine analogues. Synthesis and preliminary pharmacological evaluation of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes
D. Passarella;G. Lesma;A. Silvani;B. Danieli;
2003
Abstract
Synthesis of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes by cycloaddition and subsequent cross-coupling reaction is described. Binding affinity of these novel compounds towards the characteristic receptorial targets of ibogaine is illustrated. (C) 2002 Elsevier Science Lid. All rights reserved.
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