Synthesis of Delta(7,8)-morphinan-6-one by Grewe cyclization and bromoketalization reaction as crucial steps is described. Introduction of a hydroxyl group at 14-position is demonstrated by direct oxidation with MnO2 in the presence of silica gel. (C) 2002 Elsevier Science Ltd. All rights reserved.
A convenient synthesis of Delta(7,8)-morphinan-6-one and its direct oxidation to 14-hydroxy-Delta(7,8)-morphinan-6-one / D. Passarella, A. Consonni, A. Giardini, G. Lesma, A. Silvani. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - 12:15(2002), pp. 1981-1983.
A convenient synthesis of Delta(7,8)-morphinan-6-one and its direct oxidation to 14-hydroxy-Delta(7,8)-morphinan-6-one
D. PassarellaPrimo
;G. LesmaPenultimo
;A. SilvaniUltimo
2002
Abstract
Synthesis of Delta(7,8)-morphinan-6-one by Grewe cyclization and bromoketalization reaction as crucial steps is described. Introduction of a hydroxyl group at 14-position is demonstrated by direct oxidation with MnO2 in the presence of silica gel. (C) 2002 Elsevier Science Ltd. All rights reserved.
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
