A panel of ordered YAC clones, isolated using STSs in the Xq13-Xq23 region, was used to characterize by Fluorescent In Situ Hybridization (FISH) the Xq21 breakpoint in a t(X;1)(q21;p34) translocation female with premature ovarian failure. The YAC 949E11 was found to span the breakpoint, but also to join the two non-overlapping YACs 36CB1 and 40AB3, proximal and distal, respectively, to the patient's Xq21 breakpoint.
FISH characterization of the Xq21 breakpoint in a translocation carrier with premature ovarian failure / P. Riva, I. Magnani, A. M. Fuhrman Conti, D. Gelli, C. Sala, D. Toniolo, L. Larizza. - In: CLINICAL GENETICS. - ISSN 0009-9163. - 50:4(1996 Oct), pp. 267-9-269.
Titolo: | FISH characterization of the Xq21 breakpoint in a translocation carrier with premature ovarian failure |
Autori: | |
Parole Chiave: | Chromosomes, Human, Pair 1; DNA Probes; X Chromosome; Primary Ovarian Insufficiency; Humans; Heterozygote; In Situ Hybridization, Fluorescence; Adolescent; Female; Chromosomes, Artificial, Yeast; Translocation, Genetic |
Data di pubblicazione: | ott-1996 |
Rivista: | |
Tipologia: | Article (author) |
Appare nelle tipologie: | 01 - Articolo su periodico |