A panel of ordered YAC clones, isolated using STSs in the Xq13-Xq23 region, was used to characterize by Fluorescent In Situ Hybridization (FISH) the Xq21 breakpoint in a t(X;1)(q21;p34) translocation female with premature ovarian failure. The YAC 949E11 was found to span the breakpoint, but also to join the two non-overlapping YACs 36CB1 and 40AB3, proximal and distal, respectively, to the patient's Xq21 breakpoint.
|Titolo:||FISH characterization of the Xq21 breakpoint in a translocation carrier with premature ovarian failure|
|Parole Chiave:||Chromosomes, Human, Pair 1; DNA Probes; X Chromosome; Primary Ovarian Insufficiency; Humans; Heterozygote; In Situ Hybridization, Fluorescence; Adolescent; Female; Chromosomes, Artificial, Yeast; Translocation, Genetic|
|Data di pubblicazione:||ott-1996|
|Appare nelle tipologie:||01 - Articolo su periodico|