A panel of ordered YAC clones, isolated using STSs in the Xq13-Xq23 region, was used to characterize by Fluorescent In Situ Hybridization (FISH) the Xq21 breakpoint in a t(X;1)(q21;p34) translocation female with premature ovarian failure. The YAC 949E11 was found to span the breakpoint, but also to join the two non-overlapping YACs 36CB1 and 40AB3, proximal and distal, respectively, to the patient's Xq21 breakpoint.
FISH characterization of the Xq21 breakpoint in a translocation carrier with premature ovarian failure / P. Riva, I. Magnani, A. M. Fuhrman Conti, D. Gelli, C. Sala, D. Toniolo, L. Larizza. - In: CLINICAL GENETICS. - ISSN 0009-9163. - 50:4(1996 Oct), pp. 267-9-269.
FISH characterization of the Xq21 breakpoint in a translocation carrier with premature ovarian failure
P. Riva;I. Magnani;A. M. Fuhrman Conti;L. Larizza
1996
Abstract
A panel of ordered YAC clones, isolated using STSs in the Xq13-Xq23 region, was used to characterize by Fluorescent In Situ Hybridization (FISH) the Xq21 breakpoint in a t(X;1)(q21;p34) translocation female with premature ovarian failure. The YAC 949E11 was found to span the breakpoint, but also to join the two non-overlapping YACs 36CB1 and 40AB3, proximal and distal, respectively, to the patient's Xq21 breakpoint.
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