A case of triphenyltin acetate (TPTA) poisoning is described. The patient, who had been exposed mainly to cutaneous absorption, showed acute stages of an urticarial eruption, signs of hepatic injury, slight glucose intolerance, and electroencephalographic abnormalities. Concomitant with the highest concentrations of tin in plasma and the peak of tin excretion in urine, neutrophils did not show the normal increase in actin polymerisation after stimulation with a chemotactic peptide (100 nM fMLP). The peak of urinary excretion of tin occurred between the fifth and the sixth jday after poisoning; subsequently, the rate of excretion became slow, suggesting biphasic kinetics with the possibility of a cumulative trend.

Occupational triphenyltin acetate poisoning: a case report / C. Colosio, M. Tomasini, S. Cairoli, V. Foa, C. Minoia, M. Marinovich, C.L. Galli. - In: BRITISH JOURNAL OF INDUSTRIAL MEDICINE. - ISSN 0007-1072. - 48:2(1991), pp. 136-139.

Occupational triphenyltin acetate poisoning: a case report

C. Colosio
Primo
;
V. Foa;M. Marinovich
Penultimo
;
C.L. Galli
Ultimo
1991

Abstract

A case of triphenyltin acetate (TPTA) poisoning is described. The patient, who had been exposed mainly to cutaneous absorption, showed acute stages of an urticarial eruption, signs of hepatic injury, slight glucose intolerance, and electroencephalographic abnormalities. Concomitant with the highest concentrations of tin in plasma and the peak of tin excretion in urine, neutrophils did not show the normal increase in actin polymerisation after stimulation with a chemotactic peptide (100 nM fMLP). The peak of urinary excretion of tin occurred between the fifth and the sixth jday after poisoning; subsequently, the rate of excretion became slow, suggesting biphasic kinetics with the possibility of a cumulative trend.
Settore MED/44 - Medicina del Lavoro
Settore BIO/14 - Farmacologia
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1035334/
Article (author)
File in questo prodotto:
File Dimensione Formato  
Tripheyltin_1991.pdf

accesso aperto

Tipologia: Pre-print (manoscritto inviato all'editore)
Dimensione 645.29 kB
Formato Adobe PDF
645.29 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/181071
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 51
  • ???jsp.display-item.citation.isi??? ND
social impact