The in vitro effects of two omega-3 polyunsaturated fatty acids (PUFAs), namely eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), on some inflammatory functions of goat monocytes including phagocytosis, extracellular respiratory burst, as well as the capability to modulate the expression of some pro-inflammatory cytokines, were investigated. Their apoptosis rate and cytoplasmic accumulation of lipid droplets were also studied. Six clinically healthy multiparous lactating goats (Saanen) between 5 and 6 years of age and between 30 and 33 weeks after calving were used for blood collection. Both EPA and DHA upregulated the phagocytosis of monocytes. Results on cytokine regulatory activity were inconsistent. Both EPA and DHA treatment induced a different accumulation of lipid droplets in goat monocytes. Profound effects of EPA and DHA on cellular lipid accumulation were observed. This study demonstrated that both EPA and DHA had important and specific roles in modulating monocyte immune functions and therefore support their use in animal diets not only to increase the nutritional value of milk for human consumption, but also because they could improve animal health.
Modulation of goat monocyte immune functions by omega-3 polyunsaturated fatty acids EPA and DHA / G. Savoini, C. Lecchi, A. Agazzi, S. Modina, M. Ferroni, L. Pisani, G. Invernizzi, P. Sartorelli, F. Ceciliani (PUBLICATION - EUROPEAN ASSOCIATION FOR ANIMAL PRODUCTION). - In: Energy and protein metabolism and nutrition / [a cura di] G.M. Crovetto. - Wageningen : Wageningen academic publishers, 2010. - ISBN 9789086861538. - pp. 503-504 (( Intervento presentato al 3. convegno International symposium on energy and protein metabolism and nutrition tenutosi a Parma nel 2010.
|Titolo:||Modulation of goat monocyte immune functions by omega-3 polyunsaturated fatty acids EPA and DHA|
SAVOINI, GIOVANNI (Primo)
LECCHI, CRISTINA (Secondo)
SARTORELLI, PAOLA (Penultimo)
CECILIANI, FABRIZIO (Ultimo)
|Settore Scientifico Disciplinare:||Settore VET/01 - Anatomia degli Animali Domestici|
Settore VET/03 - Patologia Generale e Anatomia Patologica Veterinaria
Settore AGR/18 - Nutrizione e Alimentazione Animale
|Data di pubblicazione:||2010|
|Enti collegati al convegno:||EAAP|
European federation for animal science
|Tipologia:||Book Part (author)|
|Appare nelle tipologie:||03 - Contributo in volume|