The lipase-catalysed kinetic resolution of flurbiprofen was performed in a flow-chemistry reactor allowing for a significant reduction of the reaction time compared to the classical batch method. The process was implemented by adding an in-line purification step of the exiting solution, consisting in a catch and release protocol, which allows easy separation and recovery of both (S)-flurbiprofen and (R)-flurbiprofen butyl ester with an enantiomeric excess >= 90% and a chemical purity >98%.

An efficient method for the lipase-catalysed resolution and in-line purification of racemic flurbiprofen in a continuous-flow reactor / L. Tamborini, D. Romano, A. Pinto, A. Bertolani, F. Molinari, P. Conti. - In: JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC. - ISSN 1381-1177. - 84(2012 Dec), pp. 78-82. ((Intervento presentato al 10. convegno International symposium on biocatalysis and biotransformations tenutosi a Giardini Naxos nel 2011.

An efficient method for the lipase-catalysed resolution and in-line purification of racemic flurbiprofen in a continuous-flow reactor

L. Tamborini
Primo
;
D. Romano
Secondo
;
A. Pinto;F. Molinari
Penultimo
;
P. Conti
Ultimo
2012

Abstract

The lipase-catalysed kinetic resolution of flurbiprofen was performed in a flow-chemistry reactor allowing for a significant reduction of the reaction time compared to the classical batch method. The process was implemented by adding an in-line purification step of the exiting solution, consisting in a catch and release protocol, which allows easy separation and recovery of both (S)-flurbiprofen and (R)-flurbiprofen butyl ester with an enantiomeric excess >= 90% and a chemical purity >98%.
enzymatic resolution; flow reactor; lipase; flurbiprofen; catch and release
Settore CHIM/08 - Chimica Farmaceutica
Settore CHIM/11 - Chimica e Biotecnologia delle Fermentazioni
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/178421
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