The lipase-catalysed kinetic resolution of flurbiprofen was performed in a flow-chemistry reactor allowing for a significant reduction of the reaction time compared to the classical batch method. The process was implemented by adding an in-line purification step of the exiting solution, consisting in a catch and release protocol, which allows easy separation and recovery of both (S)-flurbiprofen and (R)-flurbiprofen butyl ester with an enantiomeric excess >= 90% and a chemical purity >98%.
An efficient method for the lipase-catalysed resolution and in-line purification of racemic flurbiprofen in a continuous-flow reactor / L. Tamborini, D. Romano, A. Pinto, A. Bertolani, F. Molinari, P. Conti. - In: JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC. - ISSN 1381-1177. - 84(2012 Dec), pp. 78-82. ((Intervento presentato al 10. convegno International symposium on biocatalysis and biotransformations tenutosi a Giardini Naxos nel 2011.
An efficient method for the lipase-catalysed resolution and in-line purification of racemic flurbiprofen in a continuous-flow reactor
L. TamboriniPrimo
;D. RomanoSecondo
;A. Pinto;F. MolinariPenultimo
;P. ContiUltimo
2012
Abstract
The lipase-catalysed kinetic resolution of flurbiprofen was performed in a flow-chemistry reactor allowing for a significant reduction of the reaction time compared to the classical batch method. The process was implemented by adding an in-line purification step of the exiting solution, consisting in a catch and release protocol, which allows easy separation and recovery of both (S)-flurbiprofen and (R)-flurbiprofen butyl ester with an enantiomeric excess >= 90% and a chemical purity >98%.
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