The design, synthesis, in vitro and in vivo activities of novel benzoyl and cinnamoyl nitrogenmustard and half-mustardderivatives of distamycinA are described and structure-activity relationships are discussed. The equipotent activities of N-ethyl-N-chloroethyl half-mustards and N,N-dichloroethyl mustards and the superior activities of cinnamoyl derivatives are the most relevant features of the series.
Novel phenyl nitrogen mustard and half-mustard derivatives of distamycin A / P. Cozzi, I. Beria, G. Biasoli, M. Caldarelli, L. Capolongo, R. D'Alessio, C. Geroni, S. Mazzini, E. Ragg, C. Rossi, N. Mongelli. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - 7:23(1997), pp. 2985-2990.
Titolo: | Novel phenyl nitrogen mustard and half-mustard derivatives of distamycin A | |
Autori: | ||
Settore Scientifico Disciplinare: | Settore CHIM/06 - Chimica Organica | |
Data di pubblicazione: | 1997 | |
Rivista: | ||
Tipologia: | Article (author) | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/S0960-894X(97)10121-4 | |
Appare nelle tipologie: | 01 - Articolo su periodico |