The design, synthesis, in vitro and in vivo activities of novel benzoyl and cinnamoyl nitrogenmustard and half-mustardderivatives of distamycinA are described and structure-activity relationships are discussed. The equipotent activities of N-ethyl-N-chloroethyl half-mustards and N,N-dichloroethyl mustards and the superior activities of cinnamoyl derivatives are the most relevant features of the series.
Novel phenyl nitrogen mustard and half-mustard derivatives of distamycin A / P. Cozzi, I. Beria, G. Biasoli, M. Caldarelli, L. Capolongo, R. D'Alessio, C. Geroni, S. Mazzini, E. Ragg, C. Rossi, N. Mongelli. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - 7:23(1997), pp. 2985-2990.
Novel phenyl nitrogen mustard and half-mustard derivatives of distamycin A
S. Mazzini;E. Ragg;
1997
Abstract
The design, synthesis, in vitro and in vivo activities of novel benzoyl and cinnamoyl nitrogenmustard and half-mustardderivatives of distamycinA are described and structure-activity relationships are discussed. The equipotent activities of N-ethyl-N-chloroethyl half-mustards and N,N-dichloroethyl mustards and the superior activities of cinnamoyl derivatives are the most relevant features of the series.
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